Brazilian copaifera species: Antifungal activity against clinically relevant candida species, cellular target, and in vivo toxicity

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Franca-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAndrade, Géssica-
Autor(es): dc.creatorOrlando, Haniel Chadwick Silva-
Autor(es): dc.creatorScorzoni, Liliana [UNESP]-
Autor(es): dc.creatorPedroso, Reginaldo Santos-
Autor(es): dc.creatorAbrão, Fariza-
Autor(es): dc.creatorCarvalho, Marco Túlio Menezes-
Autor(es): dc.creatorVeneziani, Rodrigo Cassio Sola-
Autor(es): dc.creatorAmbrósio, Sérgio Ricardo-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorMendes-Giannini, Maria José Soares [UNESP]-
Autor(es): dc.creatorMartins, Carlos Henrique Gomes-
Autor(es): dc.creatorPires, Regina Helena-
Data de aceite: dc.date.accessioned2022-02-22T00:52:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:18Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof6030153-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208067-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208067-
Descrição: dc.descriptionPlants belonging to the genus Copaifera are widely used in Brazil due to their antimicrobial properties, among others. The re-emergence of classic fungal diseases as a consequence of antifungal resistance to available drugs has stimulated the search for plant-based compounds with antifungal activity, especially against Candida. The Candida-infected Caenorhabditis elegans model was used to evaluate the in vitro antifungal potential of Copaifera leaf extracts and trunk oleoresins against Candida species. The Copaifera leaf extracts exhibited good antifungal activity against all Candida species, with MIC values ranging from 5.86 to 93.75 µg/mL. Both the Copaifera paupera and Copaifera reticulata leaf extracts at 46.87 µg/mL inhibited Candida glabrata biofilm formation and showed no toxicity to C. elegans. The survival of C. glabrata-infected nematodes increased at all the tested extract concentrations. Exposure to Copaifera leaf extracts markedly increased C. glabrata cell vacuolization and cell membrane damage. Therefore, Copaifera leaf extracts are potential candidates for the development of new and safe antifungal agents.-
Descrição: dc.descriptionUniversity of Franca-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionScience and Technology Institute of São José dos Campos ICT São Paulo State University (UNESP)-
Descrição: dc.descriptionHealth Technical School (ESTES) Federal University of Uberlandia-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo-
Descrição: dc.descriptionInstitute of Biomedical Sciences (ICBIM) Federal University of Uberlandia-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionScience and Technology Institute of São José dos Campos ICT São Paulo State University (UNESP)-
Formato: dc.format1-12-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal-
Palavras-chave: dc.subjectC. elegans–Candida infected model-
Palavras-chave: dc.subjectCandida-
Palavras-chave: dc.subjectCopaifera-
Título: dc.titleBrazilian copaifera species: Antifungal activity against clinically relevant candida species, cellular target, and in vivo toxicity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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