Hyptis suaveolens (L.) Poit protects colon from TNBS-induced inflammation via immunomodulatory, antioxidant and anti-proliferative mechanisms

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.contributorUniversidade Federal do Ceará (UFC)-
Autor(es): dc.contributorUniversidade Federal do Rio Grande Norte (UFRN)-
Autor(es): dc.contributorFederal University of Rio Grande do Norte-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMachado, Flávia Danniele Frota-
Autor(es): dc.creatorFormiga, Rodrigo de Oliveira-
Autor(es): dc.creatorLima, Gedson Rodrigues de Morais-
Autor(es): dc.creatorde Jesus, Neyres Zínia Taveira-
Autor(es): dc.creatorAlves Júnior, Edvaldo Balbino-
Autor(es): dc.creatorMarinho, Alexsandro Fernandes-
Autor(es): dc.creatorTavares, Josean Fechine-
Autor(es): dc.creatorSantos, Flávia Almeida-
Autor(es): dc.creatorViana, Ana Flávia Seraine Custódio-
Autor(es): dc.creatorAraújo, Aurigena Antunes-
Autor(es): dc.creatorde Araújo Júnior, Raimundo Fernandes-
Autor(es): dc.creatorPellizzon, Cláudia Helena [UNESP]-
Autor(es): dc.creatorBatista, Leônia Maria-
Data de aceite: dc.date.accessioned2022-02-22T00:52:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:11Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2020.113153-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208021-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208021-
Descrição: dc.descriptionEthnopharmacological relevance: In folk medicine Hyptis suaveolens (Lamiaceae) has been reported to relieve respiratory and gastrointestinal infections, indigestion, cold, pain, fever, cramps, skin diseases, gastric ulcer and inflammatory disorders. This study investigated the effects and the mechanisms of action of Hyptis suaveolens (L.) Poit (Lamiaceae) ethanol extract (Hs-EtOH) and hexane phase (Hs-HexF) against intestinal inflammation. Material and methods: Acute and relapse TNBS-induced ulcerative colitis protocols were used to evaluate intestinal anti-inflammatory activity. Damage evaluations, biochemical, histological and immunostaining parameters were determined. Results: Both extracts decreased macroscopic colonic inflammation and the area of lesion induced by TNBS. Nevertheless, only Hs-HexF was able to reduce colonic wall thickness, edema and diffuse inflammatory cell infiltration and to prevent GSH depletion in the acute model of ulcerative colitis. In the chronic phase with relapse of colonic ulceration, yet again only Hs-HexF significantly attenuated inflammatory parameters and presented a decrease in nitrite/nitrate, MDA, MPO, IL-1-β and TNF-α and increased levels of SOD, CAT, GSH and IL-10. Hs-HexF also significantly reduced positive cells immunostained for PCNA. Conclusion: The data indicate intestinal anti-inflammatory activity for H. suaveolens, due to the participation of the antioxidant system, decreased neutrophil infiltration and cytokine modulation, as well as, owing to regulation of cell proliferation.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Program in Natural and Synthetic Bioactive Products Health Sciences Center Universidade Federal da Paraíba (UFPB)-
Descrição: dc.descriptionLaboratory of Natural Products Universidade Federal do Ceará (UFC)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Universidade Federal do Rio Grande Norte (UFRN)-
Descrição: dc.descriptionDepartment of Morphology Histology and Basic Pathology Federal University of Rio Grande do Norte-
Descrição: dc.descriptionLaboratory of Histology UNIPEX-FMB Universidade de São Paulo (UNESP)-
Descrição: dc.descriptionLaboratory of Histology UNIPEX-FMB Universidade de São Paulo (UNESP)-
Descrição: dc.descriptionCNPq: 14/2014-
Idioma: dc.languageen-
Relação: dc.relationJournal of Ethnopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHyptis suaveolens-
Palavras-chave: dc.subjectIntestinal anti-inflammatory activity-
Palavras-chave: dc.subjectMedicinal plant-
Título: dc.titleHyptis suaveolens (L.) Poit protects colon from TNBS-induced inflammation via immunomodulatory, antioxidant and anti-proliferative mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.