Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Roraima (UFRR)-
Autor(es): dc.contributorBrasil University-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorFaculty of Medicine São Leopoldo Mandic-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorFeitosa, Natália Martins-
Autor(es): dc.creatorGomes, Juliana Moreira Mendonça-
Autor(es): dc.creatorde Melo Hoyos, Daniela Chemim-
Autor(es): dc.creatorMattioli, Cristiano Campos [UNESP]-
Autor(es): dc.creatorEto, Silas Fernandes-
Autor(es): dc.creatorFernandes, Dayanne Carla [UNESP]-
Autor(es): dc.creatorde Andrade Belo, Marco Antonio [UNESP]-
Autor(es): dc.creatorde Oliveira Silva, Juliana-
Autor(es): dc.creatorde Barros, André Luis Branco-
Autor(es): dc.creatorJunior, Jose Dias Corrêa-
Autor(es): dc.creatorde Menezes, Gustavo Batista-
Autor(es): dc.creatorFukushima, Hirla Costa Silva-
Autor(es): dc.creatorCastro, Tássia Flávia Dias-
Autor(es): dc.creatorBorra, Ricardo Carneiro-
Autor(es): dc.creatorPierezan, Felipe-
Autor(es): dc.creatorde Melo, Nathalie Ferreira Silva-
Autor(es): dc.creatorFraceto, Leonardo Fernandes [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:06Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0238823-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207993-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207993-
Descrição: dc.descriptionMucoadhesive polymeric nanocapsules have attracted interest of researchers from different fields from natural sciences because of their ability to interact with the mucosa and increase drug permeation. Anesthesia by immersion causes absorption through the skin and gills of fish, so it is important to evaluate the exposure of these organs to drug nanosystems. Benzocaine (BENZ) is one of the most popular anesthetic agents used in fish anesthesia, but it has drawbacks because of its low bioavailability, resulting in weak absorption after immersion. Here we describe method developed for preparing and characterizing chitosan-coated PLGA mucoadhesive nanoparticles containing BENZ (NPMAs) for zebrafish immersion anesthesia. We determined the lowest effective concentration, characterized the interaction of the mucoadhesive system with fish, measured the anesthetic efficacy, and evaluated possible toxic effects in embryos and adults exposed to the nanoformulations. This study opens perspectives for using nanoformulations prepared with BENZ in aquaculture, allowing reduction of dosage as well as promoting more effective anesthesia and improved interaction with the mucoadhesive system of fish.-
Descrição: dc.descriptionDepartment of Pharmacology University of São Paulo-ICB/USP-
Descrição: dc.descriptionLaboratório Integrado de Biociências Translacionais (LIBT) Instituto de Biodiversidade e Sustentabilidade (NUPEM) Universidade Federal do Rio de Janeiro (UFRJ)-
Descrição: dc.descriptionDepartment of Morphology ICB-UFMG-
Descrição: dc.descriptionAquiculture Laboratory (Laqua) UFMG-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University-
Descrição: dc.descriptionDepartment of Postgraduate in Health Sciences PROCISA Federal University of Roraima (UFRR)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (Unesp)-
Descrição: dc.descriptionLaboratory of Animal Pharmacology and Toxicology Brasil University-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Faculty of Pharmacy-UFMG-
Descrição: dc.descriptionLaboratory of Applied Immunology Federal University of São Carlos-
Descrição: dc.descriptionSchool of Veterinary Medicine Department of Clinic and Veterinary Surgery UFMG-
Descrição: dc.descriptionFaculty of Medicine São Leopoldo Mandic-
Descrição: dc.descriptionInstitute of Science and Technology of Sorocaba São Paulo State University-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (Unesp)-
Descrição: dc.descriptionInstitute of Science and Technology of Sorocaba São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titlePotential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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