B chromosomes of multiple species have intense evolutionary dynamics and accumulated genes related to important biological processes

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCenter for Biology Science and Health-
Autor(es): dc.contributorUniversity of Connecticut (UCONN)-
Autor(es): dc.creatorAhmad, Syed F. [UNESP]-
Autor(es): dc.creatorJehangir, Maryam [UNESP]-
Autor(es): dc.creatorCardoso, Adauto L. [UNESP]-
Autor(es): dc.creatorWolf, Ivan R. [UNESP]-
Autor(es): dc.creatorMargarido, Vladimir P.-
Autor(es): dc.creatorCabral-De-Mello, Diogo C. [UNESP]-
Autor(es): dc.creatorO'Neill, Rachel-
Autor(es): dc.creatorValente, Guilherme T. [UNESP]-
Autor(es): dc.creatorMartins, Cesar [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:06Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-09-23-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12864-020-07072-1-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207990-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207990-
Descrição: dc.descriptionBackground: One of the biggest challenges in chromosome biology is to understand the occurrence and complex genetics of the extra, non-essential karyotype elements, commonly known as supernumerary or B chromosomes (Bs). The non-Mendelian inheritance and non-pairing abilities of B chromosomes make them an interesting model for genomics studies, thus bringing to bear different questions about their genetic composition, evolutionary survival, maintenance and functional role inside the cell. This study uncovers these phenomena in multiple species that we considered as representative organisms of both vertebrate and invertebrate models for B chromosome analysis. Results: We sequenced the genomes of three animal species including two fishes Astyanax mexicanus and Astyanax correntinus, and a grasshopper Abracris flavolineata, each with and without Bs, and identified their B-localized genes and repeat contents. We detected unique sequences occurring exclusively on Bs and discovered various evolutionary patterns of genomic rearrangements associated to Bs. In situ hybridization and quantitative polymerase chain reactions further validated our genomic approach confirming detection of sequences on Bs. The functional annotation of B sequences showed that the B chromosome comprises regions of gene fragments, novel genes, and intact genes, which encode a diverse set of functions related to important biological processes such as metabolism, morphogenesis, reproduction, transposition, recombination, cell cycle and chromosomes functions which might be important for their evolutionary success. Conclusions: This study reveals the genomic structure, composition and function of Bs, which provide new insights for theories of B chromosome evolution. The selfish behavior of Bs seems to be favored by gained genes/sequences.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Bioscience at Botucatu Sao Paulo State University (UNESP)-
Descrição: dc.descriptionWestern Paraná State University (UNIOESTE) Center for Biology Science and Health-
Descrição: dc.descriptionDepartment of General and Applied Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Molecular and Cell Biology University of Connecticut (UCONN)-
Descrição: dc.descriptionInstitute for Systems Genomics University of Connecticut (UCONN)-
Descrição: dc.descriptionBioprocess and Biotechnology Department Agronomical Science Faculty Sao Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Bioscience at Botucatu Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of General and Applied Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionBioprocess and Biotechnology Department Agronomical Science Faculty Sao Paulo State University - UNESP-
Idioma: dc.languageen-
Relação: dc.relationBMC Genomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEvolution-
Palavras-chave: dc.subjectExtra chromosome-
Palavras-chave: dc.subjectGenome-
Palavras-chave: dc.subjectNext generation sequencing-
Palavras-chave: dc.subjectSupernumerary chromosome-
Título: dc.titleB chromosomes of multiple species have intense evolutionary dynamics and accumulated genes related to important biological processes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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