Electrospun PCL-based nanofibers Arrabidaea chica Verlot - Pterodon pubescens Benth loaded: Synergic effect in fibroblast formation

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorQueen's University Belfast-
Autor(es): dc.contributorUniversity at Campinas-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSalles, Tais Helena Costa-
Autor(es): dc.creatorVolpe-Zanutto, Fabiana-
Autor(es): dc.creatorDe Oliveira Sousa, Ilza Maria-
Autor(es): dc.creatorMacHado, Daisy-
Autor(es): dc.creatorZanatta, Ana Caroline [UNESP]-
Autor(es): dc.creatorVilegas, Wagner [UNESP]-
Autor(es): dc.creatorLancellotti, Marcelo-
Autor(es): dc.creatorFoglio, Mary Ann-
Autor(es): dc.creatorD'Avila, Marcos Akira-
Data de aceite: dc.date.accessioned2022-02-22T00:52:04Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:04Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1088/1748-605X/ab9bb1-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207982-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207982-
Descrição: dc.descriptionThe guided tissue regeneration (GTR) technique can be applied in dentistry and other medical specializations, such as orthopedics. In modern dentistry, GTR has been used in periodontics and implantology to treat periodontal defects, to reconstruct lost, damaged and atrophied bone tissue in dental implant procedures, and to preserve alveolar bases after tooth extraction. In order to create and improve new therapies and to develop new biomaterials that restore, improve and prevent aggravation of compromised tissue function, poly (ϵ-caprolactone) (PCL) polymer membranes were obtained by the electrospinning process and were associated with two plant extracts: Pterodon pubescens Benth (P. pubescens) and Arrabidaea chica Verlot (A. chica) which are characterized by their pharmacological activities of anti-inflammatory and healing actions, respectively. Fiber morphology was analyzed using scanning electron microscopy (SEM), where fiber average diameter was measured from SEM images. Contact angle measurements were performed in order to evaluate the hydrophilicity of electrospun membranes containing vegetal extract. High-performance liquid chromatography was used to evaluate the ability to release active ingredients. Cytotoxicity and cell proliferation assays were performed in vitro on NIH-3T3 cells for 1, 3 and 7 d. Electrospun PCL membranes associated with plant extracts P. pubescens and/or A. chica presented a controlled release profile of the active compounds induced fibroblast formation, suggesting that they are promising and suitable for applications in GTR.-
Descrição: dc.descriptionDepartment of Manufacturing and Materials Engineering School of Mechanical Engineering University of Campinas UNICAMP-
Descrição: dc.descriptionSchool of Pharmacy Queen's University Belfast-
Descrição: dc.descriptionGraduate School of Bioscience and Technology of Bioactive Products Biology Institute University at Campinas-
Descrição: dc.descriptionFaculdade de Ciências Médicas Universidade Estadual de Campinas UNICAMP-
Descrição: dc.descriptionFaculty of Pharmaceutical Science University at Campinas-
Descrição: dc.descriptionInstituto de Biociencias Univ Estadual Paulista UNESP-
Descrição: dc.descriptionInstituto de Biociencias Univ Estadual Paulista UNESP-
Idioma: dc.languageen-
Relação: dc.relationBiomedical Materials (Bristol)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArrabidaea chica-
Palavras-chave: dc.subjectGuided tissue regeneration-
Palavras-chave: dc.subjectPoly (ϵ-caprolactone)-
Palavras-chave: dc.subjectPterodon pubescens-
Título: dc.titleElectrospun PCL-based nanofibers Arrabidaea chica Verlot - Pterodon pubescens Benth loaded: Synergic effect in fibroblast formation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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