Genome-wide association study identified genomic regions and putative candidate genes affecting meat color traits in Nellore cattle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAnimal Science Institute-
Autor(es): dc.contributorNational Council for Science and Technological Development (CNPq)-
Autor(es): dc.creatorMarín-Garzón, N. A. [UNESP]-
Autor(es): dc.creatorMagalhães, A. F.B.-
Autor(es): dc.creatorMota, L. F.M. [UNESP]-
Autor(es): dc.creatorFonseca, L. F.S. [UNESP]-
Autor(es): dc.creatorChardulo, L. A.L. [UNESP]-
Autor(es): dc.creatorAlbuquerque, L. G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:00Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.meatsci.2020.108288-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207969-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207969-
Descrição: dc.descriptionSingle and multiple-trait GWAS were conducted to detect genomic regions and candidate genes associated with meat color traits (L*, lightness; a*, redness; b*, yellowness) in Nellore cattle. Phenotypic records of 5000 animals, and 3794 genotypes for 614,274 SNPs were used. The BLUPF90 family programs were used through single step GWAS approach. The top 10 genomic regions from single-trait GWAS explained 13.64%, 15.12% and 13% of genetic variance of L*, a* and b*, which harbored 129, 70, and 84 candidate genes, respectively. Regarding multiple-trait GWAS, the top 10 SNP windows explained 17.46%, 18.98% and 13.74% of genetic variance of L*, a* and b*, and harbored 124, 86, and 82 candidate genes, respectively. Pleiotropic effects were evidenced by the overlapping regions detected on BTA 15 and 26 associated with L* and a* (genetic correlation of −0.53), and on BTA 18 associated with a* and b* (genetic correlation of 0.60). Similar genomic regions located on BTA 2, 5, 6, and 18 were detected through single and multi-trait GWAS. Overlapped regions harbored a total of 30 functional candidate genes involved in mitochondrial activity, structural integrity of muscles, lipid oxidation, anaerobic metabolism, and muscular pH.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Agricultural and Veterinarian Sciences, Via de Acesso Professor Paulo Donato Castelane Castellane S/N - Vila Industrial-
Descrição: dc.descriptionAPTA Beef Cattle Center Animal Science Institute, Sertãozinho-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Veterinary and Animal Science-
Descrição: dc.descriptionNational Council for Science and Technological Development (CNPq)-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Agricultural and Veterinarian Sciences, Via de Acesso Professor Paulo Donato Castelane Castellane S/N - Vila Industrial-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Veterinary and Animal Science-
Idioma: dc.languageen-
Relação: dc.relationMeat Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeef-
Palavras-chave: dc.subjectGWAS-
Palavras-chave: dc.subjectMuscle coloring-
Palavras-chave: dc.subjectVariation-
Palavras-chave: dc.subjectZebu-
Título: dc.titleGenome-wide association study identified genomic regions and putative candidate genes affecting meat color traits in Nellore cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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