NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia

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Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Mississippi Medical Center-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPereira, Daniela A.-
Autor(es): dc.creatorSandrim, Valeria C. [UNESP]-
Autor(es): dc.creatorPalei, Ana C.-
Autor(es): dc.creatorAmaral, Lorena M.-
Autor(es): dc.creatorBelo, Vanessa A.-
Autor(es): dc.creatorLacchini, Riccardo-
Autor(es): dc.creatorCavalli, Ricardo C.-
Autor(es): dc.creatorTanus-Santos, Jose E.-
Autor(es): dc.creatorLuizon, Marcelo R.-
Data de aceite: dc.date.accessioned2022-02-22T00:51:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:57Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/pgs-2021-0006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207954-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207954-
Descrição: dc.descriptionAim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.-
Descrição: dc.descriptionGraduate Program in Genetics Institute of Biological Sciences Federal University of Minas Gerais-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Surgery University of Mississippi Medical Center-
Descrição: dc.descriptionDepartment of Pharmacology and Toxicology University of Mississippi Medical Center-
Descrição: dc.descriptionDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto College of Nursing University of Sao Paulo-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)-
Formato: dc.format451-464-
Idioma: dc.languageen-
Relação: dc.relationPharmacogenomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantihypertensive agents-
Palavras-chave: dc.subjectgenetic polymorphisms-
Palavras-chave: dc.subjectnicotinamide phosphoribosyltransferase-
Palavras-chave: dc.subjectnitric oxide-
Palavras-chave: dc.subjectpharmacogenetics-
Palavras-chave: dc.subjectpreeclampsia-
Palavras-chave: dc.subjectsFlt-1-
Palavras-chave: dc.subjectvisfatin/NAMPT-
Título: dc.titleNAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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