The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorBrigham and Women’s Hospital and Harvard Medical School-
Autor(es): dc.contributorPio XII Foundation-
Autor(es): dc.contributorSUNY Upstate Medical University-
Autor(es): dc.contributorMcGill University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorDr. Paulo Prata – FACISB-
Autor(es): dc.contributorThe Ohio State University-
Autor(es): dc.creatorTeixeira, Silvia A.-
Autor(es): dc.creatorViapiano, Mariano S.-
Autor(es): dc.creatorAndrade, Augusto F.-
Autor(es): dc.creatorNandhu, Mohan S.-
Autor(es): dc.creatorPezuk, Julia A.-
Autor(es): dc.creatorBidinotto, Lucas T. [UNESP]-
Autor(es): dc.creatorSuazo, Veridiana K.-
Autor(es): dc.creatorNeder, Luciano-
Autor(es): dc.creatorCarlotti, Carlos G.-
Autor(es): dc.creatorBecker, Aline P.-
Autor(es): dc.creatorTone, Luiz Gonzaga-
Autor(es): dc.creatorScrideli, Carlos A.-
Data de aceite: dc.date.accessioned2022-02-22T00:51:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12035-021-02437-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207952-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207952-
Descrição: dc.descriptionGlioblastomas (GBMs), the most common and lethal primary brain tumor, show inherent infiltrative nature and high molecular heterogeneity that make complete surgical resection unfeasible and unresponsive to conventional adjuvant therapy. Due to their fast growth rate even under hypoxic and acidic conditions, GBM cells can conserve the intracellular pH at physiological range by overexpressing membrane-bound carbonic anhydrases (CAs). The synthetic sulfonamide E7070 is a potent inhibitor of CAs that harbors putative anticancer properties; however, this drug has still not been tested in GBMs. The present study aimed to evaluate the effects of E7070 on CA9 and CA12 enzymes in GBM cells as well as in the tumor cell growth, migration, invasion, and resistance to radiotherapy and chemotherapy. We found that E7070 treatment significantly reduced tumor cell growth and increased radio- and chemotherapy efficacy against GBM cells under hypoxia. Our data suggests that E7070 has therapeutic potential as a radio-chemo-sensitizing in drug-resistant GBMs, representing an attractive strategy to improve the adjuvant therapy. We showed that CA9 and CA12 represent potentially valuable therapeutic targets that should be further investigated as useful diagnostic and prognostic biomarkers for GBM tailored therapy.-
Descrição: dc.descriptionDepartment of Paediatrics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Neurosurgery Brigham and Women’s Hospital and Harvard Medical School-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital Pio XII Foundation, Rua Antenor Duarte Villela, 1331-
Descrição: dc.descriptionDepartment of Neuroscience and Physiology SUNY Upstate Medical University-
Descrição: dc.descriptionDepartment of Human Genetics McGill University-
Descrição: dc.descriptionDepartment of Genetics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Medicine UNESP – Univ. Estadual Paulista-
Descrição: dc.descriptionBarretos School of Health Sciences Dr. Paulo Prata – FACISB-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Surgery and Anatomy Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Radiation Oncology The Ohio State University-
Descrição: dc.descriptionDepartment of Pathology School of Medicine UNESP – Univ. Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationMolecular Neurobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarbonic anhydrase-
Palavras-chave: dc.subjectCell metabolism-
Palavras-chave: dc.subjectHypoxic microenvironment-
Palavras-chave: dc.subjectPDX model-
Palavras-chave: dc.subjectPH regulation-
Título: dc.titleThe Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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