The impact of P/Ca molar ratio on physicochemical and release properties of calcium polyphosphate coacervates

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorIncubadora Municipal de Araraquara-SP-
Autor(es): dc.contributorLaboratório de Biopolímeros e Biomateriais-
Autor(es): dc.contributorFaculty of Pharmacy-
Autor(es): dc.creatorMoreno de Paiva, Juliana [UNESP]-
Autor(es): dc.creatorGomes de Oliveira Barud, Hélida-
Autor(es): dc.creatorFranco, Douglas Faza [UNESP]-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorRibeiro, António José-
Autor(es): dc.creatorBarud, Hernane S.-
Autor(es): dc.creatorNalin, Marcelo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:48Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:48Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.matchemphys.2021.124471-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207917-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207917-
Descrição: dc.descriptionThis paper reports on the synthesis and characterization of gel-like calcium polyphosphate coacervates (Ca–PPCs) with three different [P]:[Ca] ratios as new matrixes for drug release. Caffeine and chlorhexidine were used as model drugs, showing encapsulation efficiency of up to 95.4% and 70.4%, respectively. Based on the correlation coefficient (r2) values, different in vitro release behaviors were determined. While the caffeine release followed the Weibull model, the chlorhexidine release was best described by the Korsmeyer-Peppas model. The caffeine-loaded coacervate sample with the highest Ca2+ concentration (CAFPCa0.5) showed the highest incorporation and a total drug release within 720 min. The Ca-PPC-drug interactions were evaluated by infrared and Raman spectroscopies. The Ca2+ concentration, drug molecule size and intermolecular drug/matrix interactions determined the incorporation and release of drugs in the polyphosphate coacervates. High calcium concentration led to a Ca-PPC with small and tight “cage-like” structure that better incorporated caffeine molecules because of their 4.3 times smaller size compared to chlorhexidine. In addition, caffeine interacted through van der Waals' forces with polyphosphate and its release from the coacervates was most likely to occur in relation to chlorhexidine, which interacted with the coacervates through hydrogen bonding. Thus, the calcium polyphosphate coacervates loaded with the proposed drugs can be competitive and promising as drug delivery systems.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University -UNESP-
Descrição: dc.descriptionBioSmart Nanotechnology LTDA Incubadora Municipal de Araraquara-SP, Av. Jorge Fernandes de São Mattos, 311-
Descrição: dc.descriptionUniversity of Araraquara UNIARA Laboratório de Biopolímeros e Biomateriais-
Descrição: dc.descriptionUniversity of Coimbra Faculty of Pharmacy-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University -UNESP-
Descrição: dc.descriptionFAPESP: 2013/07793–6-
Descrição: dc.descriptionFAPESP: 2018/24735–3-
Descrição: dc.descriptionFAPESP: 2018/25512–8-
Descrição: dc.descriptionCNPq: 407822/2018–6-
Idioma: dc.languageen-
Relação: dc.relationMaterials Chemistry and Physics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaffeine-
Palavras-chave: dc.subjectChlorhexidine-
Palavras-chave: dc.subjectCoacervate polyphosphate-
Palavras-chave: dc.subjectDrug delivery-
Palavras-chave: dc.subjectGel-like platform-
Título: dc.titleThe impact of P/Ca molar ratio on physicochemical and release properties of calcium polyphosphate coacervates-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.