Identification of Aortic Proteins Involved in Arterial Stiffness in Spontaneously Hypertensive Rats Treated With Perindopril:A Proteomic Approach

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMiotto, Danyelle S. [UNESP]-
Autor(es): dc.creatorDionizio, Aline-
Autor(es): dc.creatorJacomini, André M. [UNESP]-
Autor(es): dc.creatorZago, Anderson S. [UNESP]-
Autor(es): dc.creatorBuzalaf, Marília Afonso Rabelo-
Autor(es): dc.creatorAmaral, Sandra L. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:47Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:47Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-02-09-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2021.624515-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207913-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207913-
Descrição: dc.descriptionArterial stiffness, frequently associated with hypertension, is associated with disorganization of the vascular wall and has been recognized as an independent predictor of all-cause mortality. The identification of the molecular mechanisms involved in aortic stiffness would be an emerging target for hypertension therapeutic intervention. This study evaluated the effects of perindopril on pulse wave velocity (PWV) and on the differentially expressed proteins in aorta of spontaneously hypertensive rats (SHR), using a proteomic approach. SHR and Wistar rats were treated with perindopril (SHRP) or water (SHRc and Wistar rats) for 8 weeks. At the end, SHRC presented higher systolic blood pressure (SBP, +70%) and PWV (+31%) compared with Wistar rats. SHRP had higher values of nitrite concentration and lower PWV compared with SHRC. From 21 upregulated proteins in the aortic wall from SHRC, most of them were involved with the actin cytoskeleton organization, like Tropomyosin and Cofilin-1. After perindopril treatment, there was an upregulation of the GDP dissociation inhibitors (GDIs), which normally inhibits the RhoA/Rho-kinase/cofilin-1 pathway and may contribute to decreased arterial stiffening. In conclusion, the results of the present study revealed that treatment with perindopril reduced SBP and PWV in SHR. In addition, the proteomic analysis in aorta suggested, for the first time, that the RhoA/Rho-kinase/Cofilin-1 pathway may be inhibited by perindopril-induced upregulation of GDIs or increases in NO bioavailability in SHR. Therefore, we may propose that activation of GDIs or inhibition of RhoA/Rho-kinase pathway could be a possible strategy to treat arterial stiffness.-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences Federal University of Sao Carlos and São Paulo State University UFSCar/UNESP-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionPost-Graduate Program in Movement Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences Federal University of Sao Carlos and São Paulo State University UFSCar/UNESP-
Descrição: dc.descriptionPost-Graduate Program in Movement Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectACE inhibitor-
Palavras-chave: dc.subjectaorta artery-
Palavras-chave: dc.subjecthypertension-
Palavras-chave: dc.subjectproteomic analysis-
Palavras-chave: dc.subjectpulse wave velocity-
Título: dc.titleIdentification of Aortic Proteins Involved in Arterial Stiffness in Spontaneously Hypertensive Rats Treated With Perindopril:A Proteomic Approach-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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