Dexamethasone Does Not Inhibit Treadmill Training-Induced Angiogenesis in Myocardium: Role of MicroRNA-126 Pathway

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorHerrera, Naiara A. [UNESP]-
Autor(es): dc.creatorDuchatsch, Francine [UNESP]-
Autor(es): dc.creatorTardelli, Lidieli P. [UNESP]-
Autor(es): dc.creatorDionísio, Thiago J.-
Autor(es): dc.creatorSantos, Carlos F.-
Autor(es): dc.creatorAmaral, Sandra L. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:45Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/FJC.0000000000000924-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207900-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207900-
Descrição: dc.descriptionDexamethasone (DEX) has important anti-inflammatory activities; however, it induces hypertension and skeletal muscle microcirculation rarefaction. Nevertheless, nothing is known about DEX outcomes on cardiac microcirculation. By contrast, exercise training prevents skeletal and cardiac microvessel loss because of microRNA expression and a better balance between their related angiogenic and apoptotic proteins in spontaneously hypertensive rats. The purpose of this study was to investigate whether DEX and/or exercise training could induce microRNA alterations leading to cardiac angiogenesis or microvascular rarefaction. Animals performed 8 weeks of exercise training and were treated with DEX (50 μg/kg per day, subcutaneously) for 14 days. Cardiovascular parameters were measured, and the left ventricle muscle was collected for analyses. DEX treatment increased arterial pressure and did not cause cardiac microcirculation rarefaction. Treadmill training prevented the DEX-induced increase in arterial pressure. In addition, training, regardless of DEX treatment, increased microRNA-126 expression, phospho-protein kinase B/protein kinase B, and endothelial nitric oxide synthase levels associated with cardiac angiogenesis. In conclusion, this study suggests, for the first time, that treadmill training induces myocardial angiogenesis because of angiogenic pathway improvement associated with an increase in microRNA-126. Furthermore, DEX, per se, did not cause capillary density alterations and did not attenuate cardiac angiogenesis induced by training.-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University (UNESP)-
Formato: dc.format708-714-
Idioma: dc.languageen-
Relação: dc.relationJournal of cardiovascular pharmacology-
???dc.source???: dc.sourceScopus-
Título: dc.titleDexamethasone Does Not Inhibit Treadmill Training-Induced Angiogenesis in Myocardium: Role of MicroRNA-126 Pathway-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.