Probiotic supplementation in marathonists and its impact on lymphocyte population and function after a marathon: a randomized placebo-controlled double-blind study

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorJustus-Liebig-University Giessen-
Autor(es): dc.creatorBatatinha, Helena-
Autor(es): dc.creatorTavares-Silva, Edgar-
Autor(es): dc.creatorLeite, Geovana S. F.-
Autor(es): dc.creatorResende, Ayane S.-
Autor(es): dc.creatorAlbuquerque, José A. T.-
Autor(es): dc.creatorArslanian, Christina-
Autor(es): dc.creatorFock, Ricardo A.-
Autor(es): dc.creatorLancha, Antônio H.-
Autor(es): dc.creatorLira, Fabio S. [UNESP]-
Autor(es): dc.creatorKrüger, Karsten-
Autor(es): dc.creatorThomatieli-Santos, Ronaldo-
Autor(es): dc.creatorRosa-Neto, José C.-
Data de aceite: dc.date.accessioned2022-02-22T00:51:43Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:43Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-75464-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207889-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207889-
Descrição: dc.descriptionProbiotic supplementation arises as playing an immune-stimulatory role. High-intensity and -volume exercise can inhibit immune cell function, which threatens athletic performance and recovery. We hypothesized that 30 days of probiotic supplementation could stabilize the immune system of athletes preventing immune suppression after a marathon race. Twenty-seven male marathonists were double-blinded randomly into probiotic (Bifidobacterium-animalis-subsp.-Lactis (10 × 109) and Lactobacillus-Acidophilus (10 × 109) + 5 g of maltodextrin) and placebo (5 g of maltodextrin) group. They received 30 sachets and supplemented 1 portion/day during 30 days before the race. Blood were collected 30 days before (rest), 1 day before (pre), 1 h after (post) and 5 days after the race (recovery). Both chronic and acute exercise modulated a different T lymphocyte population (CD3+CD4−CD8− T-cells), increasing pre-race, decreasing post and returning to rest values at the recovery. The total number of CD8 T cell and the memory subsets statistically decreased only in the placebo group post-race. Pro-inflammatory cytokine production by stimulated lymphocytes decreased in the probiotic group after the supplementation period. 30 days of probiotic supplementation maintained CD8 T cell and effector memory cell population and played an immunomodulatory role in stimulated lymphocytes. Both, training and marathon modulated a non-classical lymphocyte population regardless of probiotic supplementation.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionImmunometabolism Research Group Institute of Biomedical Sciences University of São Paulo (USP)-
Descrição: dc.descriptionPrograma de pós-graduação em psicobiologia Universidade Federal de São Paulo-
Descrição: dc.descriptionLaboratory of Applied Nutrition and Metabolism School of Physical Education and Sports University of São Paulo-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analysis School of Pharmaceutical Sciences University of São Paulo-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP) School of Technology and Sciences-
Descrição: dc.descriptionDepartment of Exercise Physiology and Sports Therapy Justus-Liebig-University Giessen-
Descrição: dc.descriptionDepartment of Bioscience Universidade Federal de São Paulo-
Descrição: dc.descriptionDepartment of Cell and Developmental Biology University of São Paulo, 1524, Prof Lineu Prestes Av.-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP) School of Technology and Sciences-
Descrição: dc.descriptionFAPESP: 2016/10561-8-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleProbiotic supplementation in marathonists and its impact on lymphocyte population and function after a marathon: a randomized placebo-controlled double-blind study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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