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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Vicente, Luciana de Morais | - |
Autor(es): dc.creator | Castelli, Erick C. [UNESP] | - |
Autor(es): dc.creator | Veronese Rodrigues, Maria de Lourdes | - |
Autor(es): dc.creator | Deghaide, Neifi Hassan Saloum | - |
Autor(es): dc.creator | Mendes-Junior, Celso Teixeira | - |
Autor(es): dc.creator | Furtado, João M. | - |
Autor(es): dc.creator | Donadi, Eduardo Antonio | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:42Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:42Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1038/s41598-020-75639-9 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207888 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207888 | - |
Descrição: dc.description | Cytomegalovirus retinochoroiditis (CMV-R) is the primary cause of blindness among AIDS patients. Since HLA-G is associated with the modulation of the immune response, we hypothesized that variability at the 3′ untraslated region (3′UTR) of the gene could be implicated on the predisposition to CMV-R. We evaluated whether HLA-G 3′UTR influences CMV-R development in Brazilian AIDS patients. Peripheral blood DNA was obtained from two groups of patients: (1) AIDS exhibiting CMV-R (n = 40) and (2) AIDS without CMV-R (n = 147). HLA-G 3′UTR typing was performed using sequencing analysis. Allele, genotype and haplotype frequencies were evaluated using Fisher’s exact test accompanied by the calculation of the odds ratio and its 95% confidence interval (95% CI). The etiologic (EF) and preventive fractions were also estimated. Compared to AIDS patients without CMV-R, AIDS patients with CMV-R showed increased frequencies of the: (1) + 3001T allele, (2) the + 3001C/T genotype and (3) the UTR-17 (InsTTCCGTGACG) haplotype (EFs = 0.02–0.04). The UTR-3 (DelTCCGCGACG) haplotype was associated with protection against CMV-R development. Although the risk for developing CMR-V at the population level was relatively low (EF), the identification of HLA-G 3′UTR variation sites may help to further evaluate the role of post-transcriptional factors that may contribute to the existent immunosuppresion caused by HIV per se. | - |
Descrição: dc.description | Ophthalmology Division Departament of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo, Av. Bandeirantes, 3900 | - |
Descrição: dc.description | Pathology Department School of Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | Departamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo | - |
Descrição: dc.description | Clinical Immunology Division Department of Internal Medicine Ribeirão Preto Medical School University of São Paulo | - |
Descrição: dc.description | Pathology Department School of Medicine São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Scientific Reports | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Variability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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