Variability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorVicente, Luciana de Morais-
Autor(es): dc.creatorCastelli, Erick C. [UNESP]-
Autor(es): dc.creatorVeronese Rodrigues, Maria de Lourdes-
Autor(es): dc.creatorDeghaide, Neifi Hassan Saloum-
Autor(es): dc.creatorMendes-Junior, Celso Teixeira-
Autor(es): dc.creatorFurtado, João M.-
Autor(es): dc.creatorDonadi, Eduardo Antonio-
Data de aceite: dc.date.accessioned2022-02-22T00:51:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:42Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-75639-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207888-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207888-
Descrição: dc.descriptionCytomegalovirus retinochoroiditis (CMV-R) is the primary cause of blindness among AIDS patients. Since HLA-G is associated with the modulation of the immune response, we hypothesized that variability at the 3′ untraslated region (3′UTR) of the gene could be implicated on the predisposition to CMV-R. We evaluated whether HLA-G 3′UTR influences CMV-R development in Brazilian AIDS patients. Peripheral blood DNA was obtained from two groups of patients: (1) AIDS exhibiting CMV-R (n = 40) and (2) AIDS without CMV-R (n = 147). HLA-G 3′UTR typing was performed using sequencing analysis. Allele, genotype and haplotype frequencies were evaluated using Fisher’s exact test accompanied by the calculation of the odds ratio and its 95% confidence interval (95% CI). The etiologic (EF) and preventive fractions were also estimated. Compared to AIDS patients without CMV-R, AIDS patients with CMV-R showed increased frequencies of the: (1) + 3001T allele, (2) the + 3001C/T genotype and (3) the UTR-17 (InsTTCCGTGACG) haplotype (EFs = 0.02–0.04). The UTR-3 (DelTCCGCGACG) haplotype was associated with protection against CMV-R development. Although the risk for developing CMR-V at the population level was relatively low (EF), the identification of HLA-G 3′UTR variation sites may help to further evaluate the role of post-transcriptional factors that may contribute to the existent immunosuppresion caused by HIV per se.-
Descrição: dc.descriptionOphthalmology Division Departament of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo, Av. Bandeirantes, 3900-
Descrição: dc.descriptionPathology Department School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo-
Descrição: dc.descriptionClinical Immunology Division Department of Internal Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionPathology Department School of Medicine São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleVariability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis-
Tipo de arquivo: dc.typelivro digital-
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