Lidocaine administered at a continuous rate infusion does not impair left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity Center of the Integrated Colleges of Ourinhos (UniFio)-
Autor(es): dc.creatorMarques, A. E.G.W. [UNESP]-
Autor(es): dc.creatorMarques, M. G. [UNESP]-
Autor(es): dc.creatorSilveira, B. C.R. [UNESP]-
Autor(es): dc.creatorOliveira, S. P. [UNESP]-
Autor(es): dc.creatorFerraz, I. G. [UNESP]-
Autor(es): dc.creatorVentricci, A. B.G.-
Autor(es): dc.creatorSilva, N. C. [UNESP]-
Autor(es): dc.creatorNagata, W. B. [UNESP]-
Autor(es): dc.creatorFloriano, B. P.-
Autor(es): dc.creatorFerreira, W. L. [UNESP]-
Autor(es): dc.creatorSantos, P.S P. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:42Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vas.2020.100151-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207885-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207885-
Descrição: dc.descriptionLidocaine is a versatile drug that not only provides local anesthesia, but also reduces anesthetic requirements of other agents and has antiarrhythmic, pro-kinetic, anti-inflammatory, antiendotoxemic and antioxidant effects. As it is a drug commonly used in critically ill patients, its safety from the cardiovascular system should be ensured. The aim of this study was to determine the effects of a continuous rate infusion (CRI) of lidocaine on left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam by use of transthoracic echocardiography. Ten New Zealand healthy rabbits were sedated with intramuscular midazolam (1 mg/kg) and enrolled in two experimental treatments (control or lidocaine). The control treatment (CT) comprised an intravenous bolus of 0.9% sodium chloride (0.05 mL/kg) followed by CRI at 5 mL/h, whereas the lidocaine treatment (LT) comprised a bolus of 2% lidocaine without epinephrine at 1 mg/kg followed by CRI at 50 µg/kg/minute. Echocardiographic and hemodynamic variables were studied. Variables were recorded at baseline (TB) and 20, 40 and 60 minutes following start of CRI (T20, T40 and T60, respectively). No differences were found between treatments. The results of this study demonstrate that a continuous rate infusion of lidocaine at 50 µg/kg/minute does not impair echocardiographic indices of left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam.-
Descrição: dc.descriptionDepartment of Animal Clinic Surgery and Reproduction São Paulo State University (UNESP) School of Veterinary Medicine, 793 Clovis Pestana st.-
Descrição: dc.descriptionDepartment of Veterinary Medicine University Center of the Integrated Colleges of Ourinhos (UniFio), BR 153, Km 338+420m-
Descrição: dc.descriptionDepartment of Animal Clinic Surgery and Reproduction São Paulo State University (UNESP) School of Veterinary Medicine, 793 Clovis Pestana st.-
Idioma: dc.languageen-
Relação: dc.relationVeterinary and Animal Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDiastolic function, Local anesthetic-
Palavras-chave: dc.subjectHeart-
Palavras-chave: dc.subjectSystolic function-
Título: dc.titleLidocaine administered at a continuous rate infusion does not impair left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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