Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCentro Clínico de Cabeza y Cuello-
Autor(es): dc.contributorSao Paulo Federal University-
Autor(es): dc.creatorSichero, Laura-
Autor(es): dc.creatorFerreira, Silvaneide-
Autor(es): dc.creatorLópez, Rossana V. M.-
Autor(es): dc.creatorMello, Barbara P.-
Autor(es): dc.creatorCosta, Victor [UNESP]-
Autor(es): dc.creatorEl-Achkar, Vivian N. R. [UNESP]-
Autor(es): dc.creatorCarlos, Román-
Autor(es): dc.creatorRibeiro-Silva, Alfredo-
Autor(es): dc.creatorPignatari, Shirley-
Autor(es): dc.creatorKaminagakura, Estela [UNESP]-
Autor(es): dc.creatorVilla, Luisa L.-
Data de aceite: dc.date.accessioned2022-02-22T00:51:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jmv.26503-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207880-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207880-
Descrição: dc.descriptionHuman papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and 11 genetic variants in juvenile onset (JORRP) and adult onset (AORRP) laryngeal papillomas. Cases of JORRP and AORRP were collected, retrospectively. HPV detection and genotyping were accessed by polymerase chain reaction-sequencing in 67 RRP samples. Overall, the most prevalent HPV-6 variants were from B1 (55.8%) and B3 (27.9%) sublineages, whereas among HPV-11 positive samples A2 (62.5%) variants were predominant. A higher prevalence of HPV-6 B1 was observed in JORRP (83.3% B1 and 16.7% B3), compared with AORRP cases (58.3% B1 and 41.7% B3). HPV-11 A2 variants were more prevalent both in JORRP (57.2%) and in AORRP cases (70.0%). Nevertheless, with the exception that HPV-6 B1 were significantly less likely to recur, there was a lack of association between any particular HPVs 6 or 11 variant and clinicopathological features. Our data do not support an association between HPVs 6 and 11 variability and RRP.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCenter for Translational Research in Oncology Instituto do Cancer do Estado de Sao Paulo Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis São Paulo State University (UNESP)-
Descrição: dc.descriptionCentro Clínico de Cabeza y Cuello-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirao Preto Medical School Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Otorhinolaryngology and Head and Neck Surgery Sao Paulo Federal University-
Descrição: dc.descriptionDepartment of Radiology and Oncology Faculdade de Medicina Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 16/24019-0-
Descrição: dc.descriptionFAPESP: 17/23211-8-
Descrição: dc.descriptionCNPq: 303431/2018-0-
Descrição: dc.descriptionCNPq: 306326/2015-9-
Formato: dc.format3835-3840-
Idioma: dc.languageen-
Relação: dc.relationJournal of Medical Virology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcase series-
Palavras-chave: dc.subjecthuman papillomavirus-
Palavras-chave: dc.subjectrecurrent respiratory papillomatosis-
Palavras-chave: dc.subjectrisk factors-
Palavras-chave: dc.subjectvariants-
Título: dc.titlePrevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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