Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade do Oeste Paulista (UNOESTE) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Ueda, Rose Meire R. | - |
Autor(es): dc.creator | de Souza, Verena M. | - |
Autor(es): dc.creator | Magalhães, Letícia R. | - |
Autor(es): dc.creator | Chagas, Pedro Henrique N. | - |
Autor(es): dc.creator | Veras, Allice S. C. [UNESP] | - |
Autor(es): dc.creator | Teixeira, Giovana R. [UNESP] | - |
Autor(es): dc.creator | Nai, Gisele A. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:37Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:37Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/03601234.2021.1939622 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207861 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207861 | - |
Descrição: dc.description | The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is the second most widely used herbicide in the world. The objective of this study was to evaluate the neurotoxic effects and the possible role of the dysregulation of apoptosis in the genesis of brain damage in chronic exposure to 2,4-D in rats. Eighty adult male rats were distributed into eight groups (n = 10) and exposed orally (contaminated feed) and via inhalation, with two groups exposed to distilled water (control) and six to 2,4-D in three distinct concentrations. They were exposed for 6 months. A neurobehavioral assessment was performed, and the brain was collected for histopathology and immunohistochemistry. The animals in the control groups showed greater motility in the open-field test and a greater number of entries in the elevated-plus-maze test than those exposed to 2,4-D (p < 0.05). Neuronal necrosis was more incident in animals exposed to 2,4-D (p < 0.05). There was a negative correlation between the expression of BAX and the measurement of the cerebral cortex thickness (r = −0.713; p = 0.047). Regardless of the route of exposure, 2,4-D led to a deficit in neurobehavioral tests and decreased thickness of the cerebral cortex associated with increased expression of the pro-apoptotic protein BAX. | - |
Descrição: dc.description | Faculty of Psychology Universidade do Oeste Paulista (UNOESTE) | - |
Descrição: dc.description | Faculty of Medicine Universidade do Oeste Paulista (UNOESTE) | - |
Descrição: dc.description | Department of Physical Education Faculdade de Ciências e Tecnologia Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP | - |
Descrição: dc.description | Department of Pathology and Graduate Program in Animal Science Universidade do Oeste Paulista (UNOESTE) | - |
Descrição: dc.description | Department of Physical Education Faculdade de Ciências e Tecnologia Universidade Estadual Paulista “Júlio de Mesquita Filho” - UNESP | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | behavior | - |
Palavras-chave: dc.subject | cell cycle | - |
Palavras-chave: dc.subject | Central nervous system | - |
Palavras-chave: dc.subject | environment | - |
Palavras-chave: dc.subject | pesticides | - |
Título: dc.title | Neurotoxicity associated with chronic exposure to dichlorophenoxyacetic acid (2,4-D)–a simulation of environmental exposure in adult rats | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: