Challenge in the discovery of new drugs: Antimicrobial peptides against who‐list of critical and high‐priority bacteria

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.creatorRoque‐borda, Cesar Augusto [UNESP]-
Autor(es): dc.creatorda Silva, Patricia Bento-
Autor(es): dc.creatorRodrigues, Mosar Corrêa-
Autor(es): dc.creatorAzevedo, Ricardo Bentes-
Autor(es): dc.creatorDi Filippo, Leonardo [UNESP]-
Autor(es): dc.creatorDuarte, Jonatas L. [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorVicente, Eduardo Festozo [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogério [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:32Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics13060773-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207832-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207832-
Descrição: dc.descriptionBacterial resistance has intensified in recent years due to the uncontrolled use of conventional drugs, and new bacterial strains with multiple resistance have been reported. This problem may be solved by using antimicrobial peptides (AMPs), which fulfill their bactericidal activity without developing much bacterial resistance. The rapid interaction between AMPs and the bacterial cell membrane means that the bacteria cannot easily develop resistance mechanisms. In addition, various drugs for clinical use have lost their effect as a conventional treatment; however, the synergistic effect of AMPs with these drugs would help to reactivate and enhance antimicrobial activity. Their efficiency against multi‐resistant and extensively resistant bacteria has positioned them as promising molecules to replace or improve conventional drugs. In this review, we examined the importance of antimicrobial peptides and their successful activity against critical and high‐priority bacteria published in the WHO list.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionTuberculosis Research Laboratory School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Nanobiotechnology Department of Genetics and Morphology Institute of Biological Sciences University of Brasilia-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Sciences and Engineering São Paulo State University (UNESP)-
Descrição: dc.descriptionTuberculosis Research Laboratory School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Sciences and Engineering São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2018/25707‐3-
Descrição: dc.descriptionFAPESP: 2020/13497‐4-
Descrição: dc.descriptionFAPESP: 2020/16573‐3-
Descrição: dc.descriptionCNPq: 303603/2018‐6-
Descrição: dc.descriptionCNPq: 404181/2019‐8-
Descrição: dc.descriptionCNPq: 429139/2018‐7-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAMPs-
Palavras-chave: dc.subjectAntibacterial activity-
Palavras-chave: dc.subjectCritical‐priority bacteria-
Palavras-chave: dc.subjectHigh‐priority bacteria-
Palavras-chave: dc.subjectMDR-
Palavras-chave: dc.subjectXDR-
Título: dc.titleChallenge in the discovery of new drugs: Antimicrobial peptides against who‐list of critical and high‐priority bacteria-
Aparece nas coleções:Repositório Institucional - Unesp

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