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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade do Oeste Paulista | - |
Autor(es): dc.creator | Okamoto-Okubo, Celina Emiko [UNESP] | - |
Autor(es): dc.creator | Cassu, Renata Navarro | - |
Autor(es): dc.creator | Joaquim, Jean Guilherme Fernandes [UNESP] | - |
Autor(es): dc.creator | Dos Reis Mesquita, Luciane [UNESP] | - |
Autor(es): dc.creator | Rahal, Sheila Canevese [UNESP] | - |
Autor(es): dc.creator | Oliveira, Hugo S Salvador [UNESP] | - |
Autor(es): dc.creator | Takahira, Regina [UNESP] | - |
Autor(es): dc.creator | Arruda, Isadora [UNESP] | - |
Autor(es): dc.creator | Maia, Leandro [UNESP] | - |
Autor(es): dc.creator | da CRUZ LANDIM, Fernanda [UNESP] | - |
Autor(es): dc.creator | Luna, Stelio Pacca Loureiro [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:27Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:27Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1292/jvms.20-0730 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207799 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207799 | - |
Descrição: dc.description | This prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests (P<0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% (P=0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively (P=0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups (P=0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment. | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal Science | - |
Descrição: dc.description | Department of Veterinary Surgery and Anesthesiology Faculty of Veterinary Medicine Universidade do Oeste Paulista | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal Science | - |
Formato: dc.format | 881-888 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Veterinary Medical Science | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Canine | - |
Palavras-chave: dc.subject | Hip dysplasia | - |
Palavras-chave: dc.subject | Mesenchymal stem cells | - |
Palavras-chave: dc.subject | Osteoarthritis | - |
Palavras-chave: dc.subject | Platelet-rich plasma | - |
Título: dc.title | Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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