Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade do Oeste Paulista-
Autor(es): dc.creatorOkamoto-Okubo, Celina Emiko [UNESP]-
Autor(es): dc.creatorCassu, Renata Navarro-
Autor(es): dc.creatorJoaquim, Jean Guilherme Fernandes [UNESP]-
Autor(es): dc.creatorDos Reis Mesquita, Luciane [UNESP]-
Autor(es): dc.creatorRahal, Sheila Canevese [UNESP]-
Autor(es): dc.creatorOliveira, Hugo S Salvador [UNESP]-
Autor(es): dc.creatorTakahira, Regina [UNESP]-
Autor(es): dc.creatorArruda, Isadora [UNESP]-
Autor(es): dc.creatorMaia, Leandro [UNESP]-
Autor(es): dc.creatorda CRUZ LANDIM, Fernanda [UNESP]-
Autor(es): dc.creatorLuna, Stelio Pacca Loureiro [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:27Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:27Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1292/jvms.20-0730-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207799-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207799-
Descrição: dc.descriptionThis prospective, comparative, randomized, horizontal, and double-blind clinical study investigated the clinical efficacy of leucocyte-poor platelet-rich plasma (PRP, n=8) or allogeneic adipose-derived stem cells (ADSC, n=8) in dogs with bilateral degenerative hip joint disease (DHJD). Sixteen dogs were treated with two intra-articular injections of PRP or ADSCs, within a 30-day interval. The Canine Brief Pain Inventory (CBPI), the Helsinki Chronic Pain Index (HCPI), and Visual Analogue Scales for pain (VAS-pain) and locomotion (VAS-loc) were assessed by the dog owners. Analysis-of-gait using a force plate, response to palpation (VAS-palp), and the descriptive numerical scale for pain (DNS) were measured by a veterinarian. The assessments were performed before (baseline), 30 and 60 days after the first treatment. Data were analyzed using the unpaired t test, paired Wilcoxon test, Fisher’s exact test, and Mann-Whitney and Friedman tests (P<0.05). Compared with baseline HCPI, CBPI, VAS-pain, and VAS-palp scores reduced 41%, 52%, 51%, and 48% (P=0.0001–0.03) at 60 days in the ADSC group. In PRP-treated dogs, CBPI, VAS-loc, and DNS scores decreased by 43%, 43%, and 33% at 60 days, respectively (P=0.0003–0.011). Based on CBPI data, the rate of success at 60 days was 75% and 25% in the ADSC and PRP groups (P=0.13), respectively. Both therapies were apparently safe and effective to reduce chronic pain in dogs with bilateral DHJD during a 60-day period. However, a trend towards greater improvement was provided by the ADSC treatment.-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal Science-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology Faculty of Veterinary Medicine Universidade do Oeste Paulista-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Department of Veterinary Clinics São Paulo State University (Unesp) School of Veterinary Medicine and Animal Science-
Formato: dc.format881-888-
Idioma: dc.languageen-
Relação: dc.relationJournal of Veterinary Medical Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCanine-
Palavras-chave: dc.subjectHip dysplasia-
Palavras-chave: dc.subjectMesenchymal stem cells-
Palavras-chave: dc.subjectOsteoarthritis-
Palavras-chave: dc.subjectPlatelet-rich plasma-
Título: dc.titleChronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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