Redox imbalance is related to HIV and pregnancy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorManfio, Vanessa Martinez [UNESP]-
Autor(es): dc.creatorTasca, Karen Ingrid [UNESP]-
Autor(es): dc.creatorGarcia, Jessica Leite [UNESP]-
Autor(es): dc.creatorGoís, Janaina De Oliveira [UNESP]-
Autor(es): dc.creatorCorrea, Camila Renata [UNESP]-
Autor(es): dc.creatorDe Souza, Lenice Do Rosário [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:20Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0251619-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207765-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207765-
Descrição: dc.descriptionRedox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.-
Descrição: dc.descriptionDepartment of Tropical Diseases São Paulo State University-UNESP/Botucatu-Brazil-
Descrição: dc.descriptionDepartment of Microbiology and Immunology São Paulo State University-UNESP/Botucatu-Brazil-
Descrição: dc.descriptionDepartment of Medical Clinics São Paulo State University-UNESP/Botucatu-Brazil-
Descrição: dc.descriptionDepartment of Tropical Diseases São Paulo State University-UNESP/Botucatu-Brazil-
Descrição: dc.descriptionDepartment of Microbiology and Immunology São Paulo State University-UNESP/Botucatu-Brazil-
Descrição: dc.descriptionDepartment of Medical Clinics São Paulo State University-UNESP/Botucatu-Brazil-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleRedox imbalance is related to HIV and pregnancy-
Tipo de arquivo: dc.typelivro digital-
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