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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Castilla-La Mancha | - |
Autor(es): dc.contributor | State University of Paraíba (UEPB) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Oshiro, Joao Augusto | - |
Autor(es): dc.creator | Lusuardi, Angelo | - |
Autor(es): dc.creator | Beamud, Elena M. | - |
Autor(es): dc.creator | Chiavacci, Leila Aparecida [UNESP] | - |
Autor(es): dc.creator | Cuberes, M. Teresa | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:19Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:19Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3390/nano11061362 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207760 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207760 | - |
Descrição: dc.description | Ureasil-Poly(ethylene oxide) (ureasil-PEO500) and ureasil-Poly(propylene oxide) (u-PPO400) films, unloaded and loaded with dexamethasone acetate (DMA), have been investigated by car-rying out atomic force microscopy (AFM), ultrasonic force microscopy (UFM), contact-angle, and drug release experiments. In addition, X-ray diffraction, small angle X-ray scattering, and infrared spectroscopy have provided essential information to understand the films’ structural organization. Our results reveal that while in u-PEO500 DMA occupies sites near the ether oxygen and remains absent from the film surface, in u-PPO400 new crystalline phases are formed when DMA is loaded, which show up as ~30–100 nm in diameter rounded clusters aligned along a well-defined direc-tion, presumably related to the one defined by the characteristic polymer ropes distinguished on the surface of the unloaded u-POP film; occasionally, larger needle-shaped DMA crystals are also observed. UFM reveals that in the unloaded u-PPO matrix the polymer ropes are made up of strands, which in turn consist of aligned ~180 nm in diameter stiffer rounded clusters possibly formed by siloxane-node aggregates; the new crystalline phases may grow in-between the strands when the drug is loaded. The results illustrate the potential of AFM-based procedures, in combination with additional physico-chemical techniques, to picture the nanostructural arrangements in polymer matrices intended for drug delivery. | - |
Descrição: dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
Descrição: dc.description | Federación Española de Enfermedades Raras | - |
Descrição: dc.description | Department of Applied Mechanics and Project Engineering University of Castilla-La Mancha, Plaza Manuel Meca 1 | - |
Descrição: dc.description | Laboratory of Development and Characterization of Pharmaceutical Products Department of Pharmacy Center for Biological and Health Sciences State University of Paraíba (UEPB) | - |
Descrição: dc.description | Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-Jaú | - |
Descrição: dc.description | Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-Jaú | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Nanomaterials | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Atomic force microscopy | - |
Palavras-chave: dc.subject | Organic-inorganic hybrid films | - |
Palavras-chave: dc.subject | Sol-gel | - |
Palavras-chave: dc.subject | Ultrasonic force microscopy | - |
Título: dc.title | Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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