Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Castilla-La Mancha-
Autor(es): dc.contributorState University of Paraíba (UEPB)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorOshiro, Joao Augusto-
Autor(es): dc.creatorLusuardi, Angelo-
Autor(es): dc.creatorBeamud, Elena M.-
Autor(es): dc.creatorChiavacci, Leila Aparecida [UNESP]-
Autor(es): dc.creatorCuberes, M. Teresa-
Data de aceite: dc.date.accessioned2022-02-22T00:51:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:19Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/nano11061362-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207760-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207760-
Descrição: dc.descriptionUreasil-Poly(ethylene oxide) (ureasil-PEO500) and ureasil-Poly(propylene oxide) (u-PPO400) films, unloaded and loaded with dexamethasone acetate (DMA), have been investigated by car-rying out atomic force microscopy (AFM), ultrasonic force microscopy (UFM), contact-angle, and drug release experiments. In addition, X-ray diffraction, small angle X-ray scattering, and infrared spectroscopy have provided essential information to understand the films’ structural organization. Our results reveal that while in u-PEO500 DMA occupies sites near the ether oxygen and remains absent from the film surface, in u-PPO400 new crystalline phases are formed when DMA is loaded, which show up as ~30–100 nm in diameter rounded clusters aligned along a well-defined direc-tion, presumably related to the one defined by the characteristic polymer ropes distinguished on the surface of the unloaded u-POP film; occasionally, larger needle-shaped DMA crystals are also observed. UFM reveals that in the unloaded u-PPO matrix the polymer ropes are made up of strands, which in turn consist of aligned ~180 nm in diameter stiffer rounded clusters possibly formed by siloxane-node aggregates; the new crystalline phases may grow in-between the strands when the drug is loaded. The results illustrate the potential of AFM-based procedures, in combination with additional physico-chemical techniques, to picture the nanostructural arrangements in polymer matrices intended for drug delivery.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFederación Española de Enfermedades Raras-
Descrição: dc.descriptionDepartment of Applied Mechanics and Project Engineering University of Castilla-La Mancha, Plaza Manuel Meca 1-
Descrição: dc.descriptionLaboratory of Development and Characterization of Pharmaceutical Products Department of Pharmacy Center for Biological and Health Sciences State University of Paraíba (UEPB)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-Jaú-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-Jaú-
Idioma: dc.languageen-
Relação: dc.relationNanomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAtomic force microscopy-
Palavras-chave: dc.subjectOrganic-inorganic hybrid films-
Palavras-chave: dc.subjectSol-gel-
Palavras-chave: dc.subjectUltrasonic force microscopy-
Título: dc.titleNanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.