Compounds with distinct targets present diverse antimicrobial and antibiofilm efficacy against candida albicans and streptococcus mutans, and combinations of compounds potentiate their effect

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorLobo, Carmélia Isabel Vitorino [UNESP]-
Autor(es): dc.creatorLopes, Ana Carolina Urbano de Araújo [UNESP]-
Autor(es): dc.creatorKlein, Marlise Inêz [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:51:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:14Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof7050340-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207731-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207731-
Descrição: dc.descriptionCandida albicans and Streptococcus mutans interact synergistically in biofilms associated with a severe form of dental caries. Their synergism is driven by dietary sucrose. Thus, it is necessary to devise strategies to hinder the development of those biofilms and prevent cavities. Six compounds [tt-farnesol (sesquiterpene alcohol that decreases the bacterium acidogenicity and aciduricity and a quorum sensing fungal molecule), myricetin (flavonoid that interferes with S. mutans exopolysaccharides production), two 2’-hydroxychalcones and 4’-hydroxychalcone (intermediate metabolites for flavonoids), compound 1771 (inhibitor of lipoteichoic synthase in Gram-positive bacteria)] with targets in both fungus and bacterium and their products were investigated for their antimicrobial and antibiofilm activities against single-species cultures. The compounds and concentrations effective on single-species biofilms were tested alone and combined with or without fluoride to control initial and pre-formed dual-species biofilms. All the selected treatments eliminated both species on initial biofilms. In contrast, some combinations eliminated the bacterium and others the fungus in pre-formed biofilms. The combinations 4’-hydroxychalcone+tt-farnesol+myricetin, 4’-hydroxychalcone+tt-farnesol+fluoride, and all compounds together with fluoride were effective against both species in pre-formed biofilms. Therefore, combinations of compounds with distinct targets can prevent C. albicans and S. mutans dual-species biofilm build-up in vitro.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (Unesp), Araraquara. Rua Humaitá, 1680-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (Unesp), Araraquara. Rua Humaitá, 1680-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 141316/2020-9-
Descrição: dc.descriptionCNPq: 409668/2018-4-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibiofilm agents-
Palavras-chave: dc.subjectAntimicrobial agents-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectExtracellular matrix-
Palavras-chave: dc.subjectStreptococcus mutans-
Título: dc.titleCompounds with distinct targets present diverse antimicrobial and antibiofilm efficacy against candida albicans and streptococcus mutans, and combinations of compounds potentiate their effect-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.