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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | University of Ninth of July (UNINOVE) | - |
Autor(es): dc.contributor | University of Bonn | - |
Autor(es): dc.creator | Nascimento-Oliveira, Jordana Inácio [UNESP] | - |
Autor(es): dc.creator | Fantinatti, Bruno Evaristo Almeida | - |
Autor(es): dc.creator | Wolf, Ivan Rodrigo [UNESP] | - |
Autor(es): dc.creator | Cardoso, Adauto Lima [UNESP] | - |
Autor(es): dc.creator | Ramos, Erica [UNESP] | - |
Autor(es): dc.creator | Rieder, Nathalie | - |
Autor(es): dc.creator | de Oliveira, Rogerio [UNESP] | - |
Autor(es): dc.creator | Martins, Cesar [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:14Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:14Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1186/s12864-021-07651-w | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207728 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207728 | - |
Descrição: dc.description | Background: B chromosomes (Bs) are extra elements observed in diverse eukaryotes, including animals, plants and fungi. Although Bs were first identified a century ago and have been studied in hundreds of species, their biology is still enigmatic. Recent advances in omics and big data technologies are revolutionizing the B biology field. These advances allow analyses of DNA, RNA, proteins and the construction of interactive networks for understanding the B composition and behavior in the cell. Several genes have been detected on the B chromosomes, although the interaction of B sequences and the normal genome remains poorly understood. Results: We identified 727 miRNA precursors in the A. latifasciata genome, 66% which were novel predicted sequences that had not been identified before. We were able to report the A. latifasciata-specific miRNAs and common miRNAs identified in other fish species. For the samples carrying the B chromosome (B+), we identified 104 differentially expressed (DE) miRNAs that are down or upregulated compared to samples without B chromosome (B−) (p < 0.05). These miRNAs share common targets in the brain, muscle and gonads. These targets were used to construct a protein-protein-miRNA network showing the high interaction between the targets of differentially expressed miRNAs in the B+ chromosome samples. Among the DE-miRNA targets there are protein-coding genes reported for the B chromosome that are present in the protein-protein-miRNA network. Additionally, Gene Ontology (GO) terms related to nuclear matrix organization and response to stimulus are exclusive to DE miRNA targets of B+ samples. Conclusions: This study is the first to report the connection of B chromosomes and miRNAs in a vertebrate species. We observed that the B chromosome impacts the miRNAs expression in several tissues and these miRNAs target several mRNAs involved with important biological processes. | - |
Descrição: dc.description | Department of Structural and Functional Biology Institute of Bioscience at Botucatu São Paulo State University (UNESP) | - |
Descrição: dc.description | Medical School University of Ninth of July (UNINOVE) | - |
Descrição: dc.description | Faculty of Mathematics and Natural Sciences University of Bonn | - |
Descrição: dc.description | Department of Biostatistics Plant Biology Parasitology and Zoology Institute of Bioscience at Botucatu São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Structural and Functional Biology Institute of Bioscience at Botucatu São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Biostatistics Plant Biology Parasitology and Zoology Institute of Bioscience at Botucatu São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | BMC Genomics | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Cichlid | - |
Palavras-chave: dc.subject | Fish | - |
Palavras-chave: dc.subject | Genomic | - |
Palavras-chave: dc.subject | RNA-seq | - |
Palavras-chave: dc.subject | Selfish element | - |
Palavras-chave: dc.subject | Small noncoding RNAs | - |
Palavras-chave: dc.subject | Supernumerary chromosome | - |
Palavras-chave: dc.subject | Teleost | - |
Palavras-chave: dc.subject | Transcriptome | - |
Título: dc.title | Differential expression of miRNAs in the presence of B chromosome in the cichlid fish Astatotilapia latifasciata | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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