Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorWatanabe, Lígia Moriguchi-
Autor(es): dc.creatorBueno, Ana Carolina-
Autor(es): dc.creatorde Lima, Livia Fernandes-
Autor(es): dc.creatorFerraz-Bannitz, Rafael-
Autor(es): dc.creatorDessordi, Renata [UNESP]-
Autor(es): dc.creatorGuimarães, Mariana Palma-
Autor(es): dc.creatorde Freitas, Maria Cristina Foss-
Autor(es): dc.creatorBarbosa, Fernando-
Autor(es): dc.creatorNavarro, Anderson Marliere-
Data de aceite: dc.date.accessioned2022-02-22T00:51:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:51:12Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S000711452100146X-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207719-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207719-
Descrição: dc.descriptionSeveral single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins, and if the variation in Se homeostasis could affect antioxidant protection, lipid profile, muscle homeostasis, and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for three months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), creatine kinase (CK) activity, and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNPs in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, triglycerides, and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNPs in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasizing the involvement of genetic variability in the response to Se consumption toward health maintenance and disease prevention.-
Descrição: dc.descriptionDepartment of Internal Medicine Ribeirão Preto Medical School University of São Paulo - FMRP/USP-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses and Bromatology Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo - FCFRP/USP-
Descrição: dc.descriptionDepartment of Pediatrics Ribeirão Preto Medical School University of São Paulo - FMRP/USP-
Descrição: dc.descriptionDepartment of Health Sciences Division of Nutrition and Metabolism Ribeirão Preto Medical School University of São Paulo - FMRP/USP-
Descrição: dc.descriptionDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences São Paulo State University - UNESP-
Idioma: dc.languageen-
Relação: dc.relationBritish Journal of Nutrition-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSelenium-
Palavras-chave: dc.subjectSelenoproteins-
Palavras-chave: dc.subjectSingle nucleotide polymorphisms-
Palavras-chave: dc.subjectStatin-
Título: dc.titleGenetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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