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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Federal de Minas Gerais (UFMG) | - |
Autor(es): dc.contributor | University of Surrey | - |
Autor(es): dc.creator | Saraiva, M. M.S. [UNESP] | - |
Autor(es): dc.creator | Rodrigues Alves, L. B. [UNESP] | - |
Autor(es): dc.creator | Monte, D. F.M. [UNESP] | - |
Autor(es): dc.creator | Ferreira, T. S. [UNESP] | - |
Autor(es): dc.creator | Benevides, V. P. [UNESP] | - |
Autor(es): dc.creator | Barbosa, F. O. [UNESP] | - |
Autor(es): dc.creator | Freitas Neto, O. C. | - |
Autor(es): dc.creator | Almeida, A. M. [UNESP] | - |
Autor(es): dc.creator | Barrow, P. A. | - |
Autor(es): dc.creator | Berchieri Junior, A. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:09Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:09Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/03079457.2021.1909703 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207703 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207703 | - |
Descrição: dc.description | Salmonella enterica serovars use self-induced intestinal inflammation to increase electron acceptor availability and to obtain a growth advantage in the host gut. There is evidence suggesting that the ability of Salmonella to use tetrathionate and 1,2-propanediol provides an advantage in murine infection. Thus, we present here the first study to evaluate both systemic infection and faecal excretion in commercial poultry challenged by Salmonella Enteritidis (SE) and S. Typhimurium (STM) harbouring deletions in ttrA and pduA genes, which are crucial to the metabolism of tetrathionate and 1,2-propanediol, respectively. Mutant strains were excreted at higher rates when compared to the wild-type strains. The highest rates were observed with white egg-layer and brown egg-layer chicks (67.5%), and broiler chicks (56.7%) challenged by SEΔttrAΔpduA, and brown egg-layer chicks (64.8%) challenged by STMΔttrAΔpduA. SEΔttrAΔpduA presented higher bacterial counts in the liver and spleen of the three chicken lineages and caecal contents from the broiler chickens, whereas STMΔttrAΔpduA presented higher counts in the liver and spleen of the broiler and brown-egg chickens for 28 days post-infection (P < 0.05). The ttrA and pduA genes do not appear to be major virulence determinants in faecal excretion or invasiveness for SE and STM in chickens. RESEARCH HIGHLIGHTSttrA and pudA do not impair gut colonization or systemic infection in chicks. Mutant strains were present in higher numbers in broilers than in laying chicks. Mutants of SE and STM showed greater pathogenicity in broiler chicks than layers. | - |
Descrição: dc.description | Laboratory of Avian Pathology Department of Pathology Theriogenology and One Health Sao Paulo State University (FCAV-Unesp) | - |
Descrição: dc.description | Department of Preventive Veterinary Medicine Veterinary School Federal University of Minas Gerais (UFMG) | - |
Descrição: dc.description | School of Veterinary Medicine and Science University of Surrey | - |
Descrição: dc.description | Laboratory of Avian Pathology Department of Pathology Theriogenology and One Health Sao Paulo State University (FCAV-Unesp) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Avian Pathology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | 1,2-propanediol | - |
Palavras-chave: dc.subject | paratyphoid infection | - |
Palavras-chave: dc.subject | poultry | - |
Palavras-chave: dc.subject | Salmonella Enteritidis | - |
Palavras-chave: dc.subject | Salmonella Typhimurium | - |
Palavras-chave: dc.subject | salmonellosis | - |
Palavras-chave: dc.subject | tetrathionate | - |
Título: dc.title | Deciphering the role of ttrA and pduA genes for Salmonella enterica serovars in a chicken infection model | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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