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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Illinois Urbana Champaign | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | University of Kentucky | - |
Autor(es): dc.contributor | Ross University School of Veterinary Medicine | - |
Autor(es): dc.contributor | University of California | - |
Autor(es): dc.creator | Segabinazzi, Lorenzo G. T. M. [UNESP] | - |
Autor(es): dc.creator | Canisso, Igor F. | - |
Autor(es): dc.creator | Podico, Giorgia | - |
Autor(es): dc.creator | Cunha, Lais L. | - |
Autor(es): dc.creator | Novello, Guilherme [UNESP] | - |
Autor(es): dc.creator | Rosser, Michael F. | - |
Autor(es): dc.creator | Loux, Shavahn C. | - |
Autor(es): dc.creator | Lima, Fabio S. | - |
Autor(es): dc.creator | Alvarenga, Marco A. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:51:07Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:51:07Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-05-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3390/antibiotics10050490 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207693 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207693 | - |
Descrição: dc.description | Microorganisms, including pathogenic or opportunistic bacteria and fungi, may gain access to the uterus during breeding, and infectious endometritis plays a major role in equine subfertility. This study aimed to assess the post-breeding inflammatory response, endometrial culture, and embryo recovery of mares susceptible to persistent breeding-induced endometritis (PBIE) treated with plasma-rich (PRP) or-poor (PPP) plasma. Mares (n = 12) susceptible to PBIE had three cycles randomly assigned to receive intrauterine infusions of lactate ringer solution (LRS, control), or autologous PRP or PPP pre-(−48 and −24 h) and post-breeding (6 and 24 h). Mares were bred with fresh semen from one stallion. Intrauterine fluid accumulation (IUF) and endometrial neutrophils were assessed every 24 h up to 96 h post-breeding. Uterine cytokines (Ilβ, IL6, CXCL8, and IL10) were evaluated before (0 h), 6, and 24 h post-breeding, and endometrial culture three and nine days after breed. Embryo flushing was performed 8 days post-ovulation. Data were analyzed with mixed model, Tukey’s post-hoc test, and multivariate regression. PRP treatment reduced endometrial neutrophils, post-breeding IUF, and pro-inflammatory cytokines when compared to control-assigned cycles, but not significantly different than PPP. Controls had a significantly higher percentage of positive bacterial cultures (33%) in comparison to PRP-assigned cycles (0%), whereas cycles treated with PPP were not significantly different from the other groups (25%). The PRP-assigned cycles had significantly greater embryo recovery rates (83%) than the control (33%), though not significantly different than PPP (60%). Plasma infusion reduced the duration and intensity of the post-breeding inflammatory response and improved embryo recovery in mares susceptible to PBIE. Platelets incrementally downregulate PBIE and appear to have a dose-dependent antimicrobial property. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | U.S. Department of Agriculture | - |
Descrição: dc.description | Department of Veterinary Clinical Medicine College of Veterinary Medicine University of Illinois Urbana Champaign, 1008 W Hazelwood Drive | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) | - |
Descrição: dc.description | Veterinary Diagnostic Laboratory College of Veterinary Medicine University of Illinois Urbana Champaign | - |
Descrição: dc.description | Maxwell H. Gluck Equine Research Center University of Kentucky | - |
Descrição: dc.description | Ross University School of Veterinary Medicine, PO Box 334 | - |
Descrição: dc.description | Department of Population Health and Reproduction School of Veterinary Medicine University of California | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University (UNESP) | - |
Descrição: dc.description | FAPESP: 2018/02856-3 | - |
Descrição: dc.description | U.S. Department of Agriculture: ILLU-888-912 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Antibiotics | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Endometrium | - |
Palavras-chave: dc.subject | Equine | - |
Palavras-chave: dc.subject | Immunomodulation | - |
Palavras-chave: dc.subject | PRP | - |
Palavras-chave: dc.subject | Uterine inflammation | - |
Título: dc.title | Intrauterine blood plasma platelet-therapy mitigates persistent breeding-induced endometritis, reduces uterine infections, and improves embryo recovery in Mares | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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