Variants at the ASIP locus contribute to coat color darkening in Nellore cattle

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInternational Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics-
Autor(es): dc.contributorAgroPartners Consulting-
Autor(es): dc.contributorPersonal-PEC-
Autor(es): dc.contributorThe University of Queensland-
Autor(es): dc.contributorCentro Universitário Católico Salesiano-
Autor(es): dc.contributorCRV Lagoa-
Autor(es): dc.contributorUniversity of Bern-
Autor(es): dc.contributorUniversity of California-
Autor(es): dc.contributorUSDA-ARS-
Autor(es): dc.contributorRecombinetics Inc.-
Autor(es): dc.creatorTrigo, Beatriz B. [UNESP]-
Autor(es): dc.creatorUtsunomiya, Adam T. H.-
Autor(es): dc.creatorFortunato, Alvaro A. A. D. [UNESP]-
Autor(es): dc.creatorMilanesi, Marco [UNESP]-
Autor(es): dc.creatorTorrecilha, Rafaela B. P.-
Autor(es): dc.creatorLamb, Harrison-
Autor(es): dc.creatorNguyen, Loan-
Autor(es): dc.creatorRoss, Elizabeth M.-
Autor(es): dc.creatorHayes, Ben-
Autor(es): dc.creatorPadula, Rômulo C. M.-
Autor(es): dc.creatorSussai, Thayla S.-
Autor(es): dc.creatorZavarez, Ludmilla B.-
Autor(es): dc.creatorCipriano, Rafael S.-
Autor(es): dc.creatorCaminhas, Maria M. T. [UNESP]-
Autor(es): dc.creatorLopes, Flavia L. [UNESP]-
Autor(es): dc.creatorPelle, Cassiano-
Autor(es): dc.creatorLeeb, Tosso-
Autor(es): dc.creatorBannasch, Danika-
Autor(es): dc.creatorBickhart, Derek-
Autor(es): dc.creatorSmith, Timothy P. L.-
Autor(es): dc.creatorSonstegard, Tad S.-
Autor(es): dc.creatorGarcia, José F. [UNESP]-
Autor(es): dc.creatorUtsunomiya, Yuri T. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:59Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:59Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12711-021-00633-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207661-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207661-
Descrição: dc.descriptionBackground: Nellore cattle (Bos indicus) are well-known for their adaptation to warm and humid environments. Hair length and coat color may impact heat tolerance. The Nellore breed has been strongly selected for white coat, but bulls generally exhibit darker hair ranging from light grey to black on the head, neck, hump, and knees. Given the potential contribution of coat color variation to the adaptation of cattle populations to tropical and sub-tropical environments, our aim was to map positional and functional candidate genetic variants associated with darkness of hair coat (DHC) in Nellore bulls. Results: We performed a genome-wide association study (GWAS) for DHC using data from 432 Nellore bulls that were genotyped for more than 777 k single nucleotide polymorphism (SNP) markers. A single major association signal was detected in the vicinity of the agouti signaling protein gene (ASIP). The analysis of whole-genome sequence (WGS) data from 21 bulls revealed functional variants that are associated with DHC, including a structural rearrangement involving ASIP (ASIP-SV1). We further characterized this structural variant using Oxford Nanopore sequencing data from 13 Australian Brahman heifers, which share ancestry with Nellore cattle; we found that this variant originates from a 1155-bp deletion followed by an insertion of a transposable element of more than 150 bp that may impact the recruitment of ASIP non-coding exons. Conclusions: Our results indicate that the variant ASIP sequence causes darker coat pigmentation on specific parts of the body, most likely through a decreased expression of ASIP and consequently an increased production of eumelanin.-
Descrição: dc.descriptionMeat and Livestock Australia-
Descrição: dc.descriptionSchool of Veterinary Medicine Araçatuba Department of Production and Animal Health São Paulo State University (Unesp)-
Descrição: dc.descriptionInternational Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics-
Descrição: dc.descriptionAgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro-
Descrição: dc.descriptionPersonal-PEC, R. Sebastião Lima, 1336-Centro-
Descrição: dc.descriptionCentre for Animal Science Queensland Alliance for Agriculture and Food Innovation The University of Queensland-
Descrição: dc.descriptionCentro Universitário Católico Salesiano-
Descrição: dc.descriptionCRV Lagoa-
Descrição: dc.descriptionInstitute of Genetics Vetsuisse-Faculty University of Bern, Bremgartenstrasse 109A-
Descrição: dc.descriptionDermfocus University of Bern, Bremgartenstrasse 109A-
Descrição: dc.descriptionDepartment of Population Health and Reproduction School of Veterinary Medicine University of California-
Descrição: dc.descriptionDairy Forage Research Center USDA-ARS, 1925 Linden Drive-
Descrição: dc.descriptionUS. Meat Animal Research Center USDA-ARS, 844 Road 313-
Descrição: dc.descriptionRecombinetics Inc.-
Descrição: dc.descriptionSchool of Agriculture and Veterinarian Sciences Jaboticabal Department of Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Veterinary Medicine Araçatuba Department of Production and Animal Health São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Agriculture and Veterinarian Sciences Jaboticabal Department of Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (Unesp)-
Descrição: dc.descriptionMeat and Livestock Australia: B.STU.2001-
Descrição: dc.descriptionMeat and Livestock Australia: L.GEN.1808-
Descrição: dc.descriptionMeat and Livestock Australia: P.PSH.0833-
Idioma: dc.languageen-
Relação: dc.relationGenetics Selection Evolution-
???dc.source???: dc.sourceScopus-
Título: dc.titleVariants at the ASIP locus contribute to coat color darkening in Nellore cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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