Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics | - |
Autor(es): dc.contributor | AgroPartners Consulting | - |
Autor(es): dc.contributor | Personal-PEC | - |
Autor(es): dc.contributor | The University of Queensland | - |
Autor(es): dc.contributor | Centro Universitário Católico Salesiano | - |
Autor(es): dc.contributor | CRV Lagoa | - |
Autor(es): dc.contributor | University of Bern | - |
Autor(es): dc.contributor | University of California | - |
Autor(es): dc.contributor | USDA-ARS | - |
Autor(es): dc.contributor | Recombinetics Inc. | - |
Autor(es): dc.creator | Trigo, Beatriz B. [UNESP] | - |
Autor(es): dc.creator | Utsunomiya, Adam T. H. | - |
Autor(es): dc.creator | Fortunato, Alvaro A. A. D. [UNESP] | - |
Autor(es): dc.creator | Milanesi, Marco [UNESP] | - |
Autor(es): dc.creator | Torrecilha, Rafaela B. P. | - |
Autor(es): dc.creator | Lamb, Harrison | - |
Autor(es): dc.creator | Nguyen, Loan | - |
Autor(es): dc.creator | Ross, Elizabeth M. | - |
Autor(es): dc.creator | Hayes, Ben | - |
Autor(es): dc.creator | Padula, Rômulo C. M. | - |
Autor(es): dc.creator | Sussai, Thayla S. | - |
Autor(es): dc.creator | Zavarez, Ludmilla B. | - |
Autor(es): dc.creator | Cipriano, Rafael S. | - |
Autor(es): dc.creator | Caminhas, Maria M. T. [UNESP] | - |
Autor(es): dc.creator | Lopes, Flavia L. [UNESP] | - |
Autor(es): dc.creator | Pelle, Cassiano | - |
Autor(es): dc.creator | Leeb, Tosso | - |
Autor(es): dc.creator | Bannasch, Danika | - |
Autor(es): dc.creator | Bickhart, Derek | - |
Autor(es): dc.creator | Smith, Timothy P. L. | - |
Autor(es): dc.creator | Sonstegard, Tad S. | - |
Autor(es): dc.creator | Garcia, José F. [UNESP] | - |
Autor(es): dc.creator | Utsunomiya, Yuri T. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:50:59Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:50:59Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1186/s12711-021-00633-2 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207661 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207661 | - |
Descrição: dc.description | Background: Nellore cattle (Bos indicus) are well-known for their adaptation to warm and humid environments. Hair length and coat color may impact heat tolerance. The Nellore breed has been strongly selected for white coat, but bulls generally exhibit darker hair ranging from light grey to black on the head, neck, hump, and knees. Given the potential contribution of coat color variation to the adaptation of cattle populations to tropical and sub-tropical environments, our aim was to map positional and functional candidate genetic variants associated with darkness of hair coat (DHC) in Nellore bulls. Results: We performed a genome-wide association study (GWAS) for DHC using data from 432 Nellore bulls that were genotyped for more than 777 k single nucleotide polymorphism (SNP) markers. A single major association signal was detected in the vicinity of the agouti signaling protein gene (ASIP). The analysis of whole-genome sequence (WGS) data from 21 bulls revealed functional variants that are associated with DHC, including a structural rearrangement involving ASIP (ASIP-SV1). We further characterized this structural variant using Oxford Nanopore sequencing data from 13 Australian Brahman heifers, which share ancestry with Nellore cattle; we found that this variant originates from a 1155-bp deletion followed by an insertion of a transposable element of more than 150 bp that may impact the recruitment of ASIP non-coding exons. Conclusions: Our results indicate that the variant ASIP sequence causes darker coat pigmentation on specific parts of the body, most likely through a decreased expression of ASIP and consequently an increased production of eumelanin. | - |
Descrição: dc.description | Meat and Livestock Australia | - |
Descrição: dc.description | School of Veterinary Medicine Araçatuba Department of Production and Animal Health São Paulo State University (Unesp) | - |
Descrição: dc.description | International Atomic Energy Agency (IAEA) Collaborating Centre On Animal Genomics and Bioinformatics | - |
Descrição: dc.description | AgroPartners Consulting, R. Floriano Peixoto, 120-Sala 43a-Centro | - |
Descrição: dc.description | Personal-PEC, R. Sebastião Lima, 1336-Centro | - |
Descrição: dc.description | Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation The University of Queensland | - |
Descrição: dc.description | Centro Universitário Católico Salesiano | - |
Descrição: dc.description | CRV Lagoa | - |
Descrição: dc.description | Institute of Genetics Vetsuisse-Faculty University of Bern, Bremgartenstrasse 109A | - |
Descrição: dc.description | Dermfocus University of Bern, Bremgartenstrasse 109A | - |
Descrição: dc.description | Department of Population Health and Reproduction School of Veterinary Medicine University of California | - |
Descrição: dc.description | Dairy Forage Research Center USDA-ARS, 1925 Linden Drive | - |
Descrição: dc.description | US. Meat Animal Research Center USDA-ARS, 844 Road 313 | - |
Descrição: dc.description | Recombinetics Inc. | - |
Descrição: dc.description | School of Agriculture and Veterinarian Sciences Jaboticabal Department of Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (Unesp) | - |
Descrição: dc.description | School of Veterinary Medicine Araçatuba Department of Production and Animal Health São Paulo State University (Unesp) | - |
Descrição: dc.description | School of Agriculture and Veterinarian Sciences Jaboticabal Department of Preventive Veterinary Medicine and Animal Reproduction São Paulo State University (Unesp) | - |
Descrição: dc.description | Meat and Livestock Australia: B.STU.2001 | - |
Descrição: dc.description | Meat and Livestock Australia: L.GEN.1808 | - |
Descrição: dc.description | Meat and Livestock Australia: P.PSH.0833 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Genetics Selection Evolution | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Variants at the ASIP locus contribute to coat color darkening in Nellore cattle | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: