Peripheral spectrum neurological disorder after arbovirus infection is associated with HLA-F variants among Northeastern Brazilians

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital da Restauração Gov. Paulo Guerra-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSonon, Paulin-
Autor(es): dc.creatorCollares, Cristhianna V.A.-
Autor(es): dc.creatorFerreira, Maria Lúcia Brito-
Autor(es): dc.creatorAlmeida, Renata Santos-
Autor(es): dc.creatorSadissou, Ibrahim-
Autor(es): dc.creatorCordeiro, Marli Tenório-
Autor(es): dc.creatorde Fátima Militão de Albuquerque, Maria-
Autor(es): dc.creatorCastelli, Erick C. [UNESP]-
Autor(es): dc.creatorLucena-Silva, Norma-
Autor(es): dc.creatorDonadi, Eduardo A.-
Data de aceite: dc.date.accessioned2022-02-22T00:50:59Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:59Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2021.104855-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207658-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207658-
Descrição: dc.descriptionIntroduction: Non-classical class I human leukocyte antigens (HLA) molecules are known to modulate the function of cytotoxic cells (NK and T CD8+) during viral infection by interacting with inhibitory/activating receptors. However, little is known about the HLA-E/-F genetic variability on arbovirus infections. Methods: We evaluated by massive parallel sequencing the full HLA-E/-F genetic diversity among patients infected during the arbovirus (ZIKV, DENV, and CHIKV) outbreak leading to a broad range of neurological complications in the Brazilian State of Pernambuco. In parallel, healthy blood donors from the same area were also studied. Plink and R software were used for genetic association study. To limit the false-positive results and enhance the reliability of the results, we adopted P-values <0.01 as significant levels. Results: Compared to controls, the HLA-F alleles: −1610 C (rs17875375), +1383 G (rs17178385), and +3537 A (rs17875384), all in complete linkage disequilibrium with each other (r2 = 1), were overrepresented in patients presenting peripheral spectrum disorders (PSD). The HLA-F*Distal-D haplotype that harbored the −1610 C allele exhibited a trend increase in PSD group. No associations were found for HLA-E. Conclusions: Our findings showed that the HLA-F genetic background seems to be more important than HLA-E on the susceptibility to PSD complications.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação Oswaldo Cruz-
Descrição: dc.descriptionImmunogenetic Laboratory Immunology Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária-
Descrição: dc.descriptionRibeirão Preto Medical School University of São Paulo, AV Bandeirantes, 3900, HC, Vila Monte Alegre-
Descrição: dc.descriptionHospital da Restauração Gov. Paulo Guerra, Av. Gov. Agamenon Magalhães, s/n, Derby-
Descrição: dc.descriptionVirology Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária-
Descrição: dc.descriptionPublic Health Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory Prof. Dr. Walter Maurício Correa, s/n Unesp, Campus de Botucatu-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Pathology School of Medicine-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory Prof. Dr. Walter Maurício Correa, s/n Unesp, Campus de Botucatu-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Pathology School of Medicine-
Descrição: dc.descriptionCNPq: 302060/2019-7-
Descrição: dc.descriptionCNPq: 310364/2015-9-
Descrição: dc.descriptionCNPq: 310892/2019-8-
Descrição: dc.descriptionCNPq: 440760/2016-0-
Descrição: dc.descriptionCAPES: 88881.130769/2016-01-
Descrição: dc.descriptionFundação Oswaldo Cruz: INOVA FIOCRUZ/02/2019 PDJ-
Idioma: dc.languageen-
Relação: dc.relationInfection, Genetics and Evolution-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArbovirus-
Palavras-chave: dc.subjectESD-
Palavras-chave: dc.subjectHLA-E-
Palavras-chave: dc.subjectHLA-F-
Palavras-chave: dc.subjectPernambuco-
Palavras-chave: dc.subjectPSD-
Título: dc.titlePeripheral spectrum neurological disorder after arbovirus infection is associated with HLA-F variants among Northeastern Brazilians-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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