Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFerrisse, Túlio Morandin [UNESP]-
Autor(es): dc.creatorRocha, Audrey Foster Lefort [UNESP]-
Autor(es): dc.creatorLança, Maria Letícia De Almeida [UNESP]-
Autor(es): dc.creatorSilveira, Heitor Albergoni [UNESP]-
Autor(es): dc.creatorAlmeida, Luciana Yamamoto [UNESP]-
Autor(es): dc.creatorBufalino, Andreia [UNESP]-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Data de aceite: dc.date.accessioned2022-02-22T00:50:58Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:58Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4322/acr.2020.219-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207654-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207654-
Descrição: dc.descriptionSpindle cell squamous cell carcinoma (SpSCC) is a rare biphasic malignant neoplasm, uncommonly affecting the oral cavity. The SpSCC diagnosis is difficult, especially when it exhibits inconspicuous morphology, inadequate tissue sampling, or association with an exuberant inflammatory reaction. Post-radiotherapy recurrent SpSCC occurring at the same site of conventional SCC is a rare phenomenon. A 59-year-old man was complained of “painful injury on the tongue” with 20 days of duration. He reported smoking and alcohol consumption. Medical history revealed conventional SCC on the tongue treated with surgery and radiotherapy 10 years ago. Intraoral examination showed a polypoid lesion with ulcerated areas, measuring 3 cm in diameter, on the tongue and floor of the mouth, at the same site of previous conventional SCC. The microscopical analysis showed small foci of carcinomatous component admixed with an exuberant inflammatory reaction. Immunohistochemistry highlighted the sarcomatoid component. Both malignant components were positive for EMA, CD138, p40 (deltaNp63), p63, and p53. Moreover, CK AE1/AE3 evidenced the carcinomatous component, whereas vimentin stained the sarcomatoid component. The Ki-67 was >10%. The current case emphasizes the importance of immunohistochemistry in the differential diagnosis of SpSCC from mimics and documents a rare complication of Ionizing Radiation.-
Descrição: dc.descriptionUniversidade Estadual de São Paulo (UNESP) Faculdade de Odontologia de Araraquara Departamento de Diagnóstico e Cirurgia Medicina Oral-
Descrição: dc.descriptionUniversidade de São Paulo (USP) Faculdade de Odontologia de Riberão Preto Departamento de Estomatologia Saúde Coletiva e Odontologia Legal Patologia Oral-
Descrição: dc.descriptionUniversidade Estadual de São Paulo (UNESP) Faculdade de Odontologia de Araraquara Departamento de Diagnóstico e Cirurgia Medicina Oral-
Idioma: dc.languageen-
Relação: dc.relationAutopsy and Case Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectRadiotherapy-
Palavras-chave: dc.subjectSquamous cell carcinoma-
Palavras-chave: dc.subjectSquamous cell carcinoma of head and neck-
Título: dc.titlePost-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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