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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.creator | Evangelista, Rodrigo P. [UNESP] | - |
Autor(es): dc.creator | Amantino, Camila F. [UNESP] | - |
Autor(es): dc.creator | Pietro, Rosemeire C.L.R. [UNESP] | - |
Autor(es): dc.creator | Sorrechia, Rodrigo [UNESP] | - |
Autor(es): dc.creator | Piazza, Rodolfo D. [UNESP] | - |
Autor(es): dc.creator | Marques, Rodrigo F.C. [UNESP] | - |
Autor(es): dc.creator | Tedesco, Antonio C. | - |
Autor(es): dc.creator | Primo, Fernando L. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:50:57Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:50:57Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.pdpdt.2021.102273 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207646 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207646 | - |
Descrição: dc.description | Antimicrobial Photodynamic Therapy (A-PDT) is a modern and non-invasive therapeutic modality. Nanostructures like the polymeric nanocapsules (NC) has proved to be a system that has enormous potential to improve current antimicrobial therapeutic practice. NC of Zinc phenyl-thio-phthalocyanine and Amphotericin B association (NC/ZnS4Pc + AMB) built with poly(lactide-co-glycolide) (PLGA) 50:50 using the preformed polymer interfacial deposition method were developed at a 0.05 mg mL− 1 theoretical concentration to improve antifungal activity with two actives association and assistance from PDTa. It showed an average particle diameter of 253.8 ± 17.3, an average polydispersity index of 0.36 ± 0.01, and a negative Zeta potential average of -31.03 ± 5.54 for 158 days. UV–vis absorption and emission spectroscopy analyses did not show changes in photophysical properties in the steady-state of NC/ZnS4Pc + AMB counterparts free ZnS4Pc. The encapsulation percentage of actives was 89.24 % and 7.40 % for ZnS4Pc and AMB, respectively. Cell viability assay using NIH/3T3 ATCC® CRL-1658 ™ cells line showed no cytotoxicity for the concentrations tested. The photodynamic activity assay using NC/ZnS4Pc + AMB diluted showed fungal toxicity against Candida albicans yeast with energetic fluences of 12 J.cm-2 and 25 J.cm-2 by a decrease in cell viability. The MFC assay demonstrated a fungistatic activity for the conditions employed in the PDTa assay. The results show that NC/ZnS4Pc + AMB is a promising nanomaterial for antimicrobial inactivation using PDT. | - |
Descrição: dc.description | Department of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University - UNESP | - |
Descrição: dc.description | Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University - UNESP | - |
Descrição: dc.description | Laboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Chemistry Center of Nanotechnology and Tissue Engineering – Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirão Preto University of São Paulo - USP | - |
Descrição: dc.description | Department of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University - UNESP | - |
Descrição: dc.description | Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University - UNESP | - |
Descrição: dc.description | Laboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Photodiagnosis and Photodynamic Therapy | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Nanocapsules | - |
Palavras-chave: dc.subject | Photodynamic therapy | - |
Palavras-chave: dc.subject | Polymeric nanomaterials | - |
Palavras-chave: dc.subject | Zinc Phenyl-thio-phthalocyanine | - |
Título: dc.title | Copolymer-nanocapsules of zinc phenyl-thio-phthalocyanine and amphotericin-B in association with antimicrobial photodynamic therapy (A-PDT) applications against Candida albicans yeasts | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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