Copolymer-nanocapsules of zinc phenyl-thio-phthalocyanine and amphotericin-B in association with antimicrobial photodynamic therapy (A-PDT) applications against Candida albicans yeasts

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorEvangelista, Rodrigo P. [UNESP]-
Autor(es): dc.creatorAmantino, Camila F. [UNESP]-
Autor(es): dc.creatorPietro, Rosemeire C.L.R. [UNESP]-
Autor(es): dc.creatorSorrechia, Rodrigo [UNESP]-
Autor(es): dc.creatorPiazza, Rodolfo D. [UNESP]-
Autor(es): dc.creatorMarques, Rodrigo F.C. [UNESP]-
Autor(es): dc.creatorTedesco, Antonio C.-
Autor(es): dc.creatorPrimo, Fernando L. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:57Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2021.102273-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207646-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207646-
Descrição: dc.descriptionAntimicrobial Photodynamic Therapy (A-PDT) is a modern and non-invasive therapeutic modality. Nanostructures like the polymeric nanocapsules (NC) has proved to be a system that has enormous potential to improve current antimicrobial therapeutic practice. NC of Zinc phenyl-thio-phthalocyanine and Amphotericin B association (NC/ZnS4Pc + AMB) built with poly(lactide-co-glycolide) (PLGA) 50:50 using the preformed polymer interfacial deposition method were developed at a 0.05 mg mL− 1 theoretical concentration to improve antifungal activity with two actives association and assistance from PDTa. It showed an average particle diameter of 253.8 ± 17.3, an average polydispersity index of 0.36 ± 0.01, and a negative Zeta potential average of -31.03 ± 5.54 for 158 days. UV–vis absorption and emission spectroscopy analyses did not show changes in photophysical properties in the steady-state of NC/ZnS4Pc + AMB counterparts free ZnS4Pc. The encapsulation percentage of actives was 89.24 % and 7.40 % for ZnS4Pc and AMB, respectively. Cell viability assay using NIH/3T3 ATCC® CRL-1658 ™ cells line showed no cytotoxicity for the concentrations tested. The photodynamic activity assay using NC/ZnS4Pc + AMB diluted showed fungal toxicity against Candida albicans yeast with energetic fluences of 12 J.cm-2 and 25 J.cm-2 by a decrease in cell viability. The MFC assay demonstrated a fungistatic activity for the conditions employed in the PDTa assay. The results show that NC/ZnS4Pc + AMB is a promising nanomaterial for antimicrobial inactivation using PDT.-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University - UNESP-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry Center of Nanotechnology and Tissue Engineering – Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirão Preto University of São Paulo - USP-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University - UNESP-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectNanocapsules-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectPolymeric nanomaterials-
Palavras-chave: dc.subjectZinc Phenyl-thio-phthalocyanine-
Título: dc.titleCopolymer-nanocapsules of zinc phenyl-thio-phthalocyanine and amphotericin-B in association with antimicrobial photodynamic therapy (A-PDT) applications against Candida albicans yeasts-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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