Neutrophil Extracellular Traps: A Perspective of Neuroinflammation and Complement Activation in Alzheimer’s Disease

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Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Paraná-
Autor(es): dc.creatorKretzschmar, Gabriela Canalli-
Autor(es): dc.creatorBumiller-Bini, Valéria-
Autor(es): dc.creatorGasparetto Filho, Miguel Angelo-
Autor(es): dc.creatorZonta, Yohan Ricci [UNESP]-
Autor(es): dc.creatorYu, Kaio Shu Tsyr [UNESP]-
Autor(es): dc.creatorde Souza, Ricardo Lehtonen R.-
Autor(es): dc.creatorDias-Melicio, Luciane Alarcão [UNESP]-
Autor(es): dc.creatorBoldt, Angelica Beate Winter-
Data de aceite: dc.date.accessioned2022-02-22T00:50:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:55Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmolb.2021.630869-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207634-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207634-
Descrição: dc.descriptionComplement system (CS) components are associated with Alzheimer’s disease (AD), the commonest cause of dementia in the world. Neutrophils can be attracted to amyloid-β plaques by several pro-inflammatory factors, including the complement anaphylatoxin C5a. They may release neutrophil extracellular traps (NETs), which are chromatin nets associated with myeloperoxidase, elastase, and other enzymes. Some CS molecules, such as C5a, C1q, and CR1, are associated with increased neutrophil recruitment and NETs release. However, the relationship between CS molecules and NETs in AD is poorly understood. In this work, we detected higher NET concentrations in plasma and serum of Brazilian AD patients, than in elderly controls (medians = 2.78 [2.07–6.19] vs. 2.23 [0.33–4.14] ng/mL, p = 0.0005). We discussed these results within the context of our former findings on complement and AD and the context of the literature on complement and NET release, suggesting both as possible therapeutic targets to prevent the progress of the disease.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Human Molecular Genetics Postgraduate Program in Genetics Department of Genetics Federal University of Paraná (UFPR)-
Descrição: dc.descriptionMedical School of Botucatu Laboratory of Immunopathology and Infectious Agents–LIAI UNIPEX–Experimental Research Unity Sector 5 São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Polymorphism and Linkage Department of Genetics Federal University of Paraná-
Descrição: dc.descriptionMedical School of Botucatu Department of Pathology São Paulo State University (UNESP)-
Descrição: dc.descriptionMedical School of Botucatu Laboratory of Immunopathology and Infectious Agents–LIAI UNIPEX–Experimental Research Unity Sector 5 São Paulo State University (UNESP)-
Descrição: dc.descriptionMedical School of Botucatu Department of Pathology São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: CAPES-40001016006P1-
Descrição: dc.descriptionCNPq: CNPq-314288/2018–0-
Descrição: dc.descriptionFAPESP: FAPESP - 2018/09706–7-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Molecular Biosciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlzheimer's Disease-
Palavras-chave: dc.subjectC1q-
Palavras-chave: dc.subjectC5a-
Palavras-chave: dc.subjectcomplement system-
Palavras-chave: dc.subjectCR1-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectneutrophil extracellular traps-
Título: dc.titleNeutrophil Extracellular Traps: A Perspective of Neuroinflammation and Complement Activation in Alzheimer’s Disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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