Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Portsmouth-
Autor(es): dc.contributorComplutense University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBezerra-Souza, Adriana-
Autor(es): dc.creatorJesus, Jéssica A.-
Autor(es): dc.creatorLaurenti, Márcia D.-
Autor(es): dc.creatorLalatsa, Aikaterini-
Autor(es): dc.creatorSerrano, Dolores R.-
Autor(es): dc.creatorPassero, Luiz Felipe D. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2021/8828750-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207630-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207630-
Descrição: dc.descriptionThe production of ergosterol lipid involves the activity of different enzymes and is a crucial event for the Leishmania membrane homeostasis. Such enzymes can be blocked by azoles and allylamines drugs, such as the antifungal butenafine chloride. This drug was active on parasites that cause cutaneous and visceral leishmaniasis. Based on the leishmanicidal activity of butenafine chloride and considering the absence of reports about the therapeutic potential of this drug in cutaneous leishmaniasis, the present work is aimed at analyzing the efficacy of butenafine formulated in two different topical delivery systems, the self-nanoemulsifying drug delivery systems (BUT-SNEDDS) and in a SNEDDS-based nanogel (BUT-SNEDDS gel) as well as in the free form in experimental cutaneous leishmaniasis. Physical studies showed that both formulations were below 300 nm with low polydispersity (<0.5) and good colloidal stability (around -25 mV). Increased steady-state flux was reported for nanoenabled butenafine formulations with reduced lag time in Franz cell diffusion assays across Strat-M membranes. No toxic or inflammatory reactions were detected in animals treated with BUT-SNEDDS, BUT-SNEDDS gel, or butenafine. Animals topically treated with butenafine (free or nanoformulated) showed small dermal lesions and low tissue parasitism. Furthermore, BUT-SNEDD gel and butenafine presented similar efficacy than the standard drug Glucantime given by the intralesional route. Increased levels of IFN-γ were observed in animals treated with BUT-SNEDDS gel or butenafine. Based on these data, the antifungal drug butenafine chloride can be considered an interesting repurposed drug for the treatment of cutaneous leishmaniasis.-
Descrição: dc.descriptionLaboratory of Pathology of Infectious Diseases (LIM-50) Medical School University of São Paulo, Avenida Dr. Arnaldo 455-
Descrição: dc.descriptionBiomaterials Bio-engineering and Nanomedicines (BioN) Laboratory Institute of Biomedical and Biomolecular Sciences School of Pharmacy and Biomedical Sciences University of Portsmouth, White Swan Road-
Descrição: dc.descriptionDepartment of Pharmaceutics and Food Technology Instituto Universitario de Farmacia Industrial (IUFI) School of Pharmacy Complutense University, Avenida Complutense-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP) São Vicente Praça Infante Dom Henrique, s/n, 11330-900-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute for Advanced Studies of Ocean São Vicente, Av. João Francisco Bensdorp, 1178-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP) São Vicente Praça Infante Dom Henrique, s/n, 11330-900-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute for Advanced Studies of Ocean São Vicente, Av. João Francisco Bensdorp, 1178-
Idioma: dc.languageen-
Relação: dc.relationJournal of Immunology Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleNanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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