Evaluation of antiplasmodial activity and cytotoxicity assays of amino acids functionalized magnetite nanoparticles: Hyperthermia and flow cytometry applications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Acre-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Lubeck-
Autor(es): dc.contributorFederal University of Rio Grande do Norte-
Autor(es): dc.contributorFoundation Oswaldo Cruz-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorRodriguez, Anselmo F.R.-
Autor(es): dc.creatordos Santos, Caio C. [UNESP]-
Autor(es): dc.creatorLüdtke-Buzug, K.-
Autor(es): dc.creatorBakenecker, Anna C.-
Autor(es): dc.creatorChaves, Yury O.-
Autor(es): dc.creatorMariúba, Luis A.M.-
Autor(es): dc.creatorBrandt, João V. [UNESP]-
Autor(es): dc.creatorAmantea, Bruno E. [UNESP]-
Autor(es): dc.creatorde Santana, Ricardo C.-
Autor(es): dc.creatorMarques, Rodrigo F.C. [UNESP]-
Autor(es): dc.creatorJafelicci, Miguel [UNESP]-
Autor(es): dc.creatorMorales, Marco A.-
Data de aceite: dc.date.accessioned2022-02-22T00:50:50Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:50Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.msec.2021.112097-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207607-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207607-
Descrição: dc.descriptionWe report the synthesis of magnetite nanoparticles (MNP) and their functionalization with glycine (MNPGly), β-alanine (MNPAla), L-phenylalanine (MNPPhAla), D-(−)-α-phenylglycine (MNPPhGly) amino acids. The functionalized nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), electron paramagnetic resonance (EPR), vibrating sample magnetometry (VSM), Mössbauer spectroscopy (MS), magnetic hyperthermia (MH), dynamic light scattering and zeta potential. The functionalized nanoparticles had isoelectric points (IEP) at pH ≃ 4.4, 5.8, 5.9 and 6.8 for samples MNPGly, MNPAla, MNPPhGly and MNPPhAla, respectively, while pure magnetite had an IEP at pH 5.6. In the MH experiments, the samples showed specific absorption rate (SAR) of 64, 71, 74, 81 and 66 W/g for MNP, MNPGly, MNPAla, MNPPhGly, and MNPPhAla, respectively. We used a flow cytometric technique to determine the cellular magnetic nanoparticles plus amino acids content. Magnetic fractionation and characterization of Resovist® magnetic nanoparticles were performed for applications in magnetic particle imaging (MPI). We have also studied the antiproliferative and antiparasitic effects of functionalized MNPs. Overall, the data showed that the functionalized nanoparticles have great potential for using as environmental, antitumor, antiparasitic agents and clinical applications.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFinanciadora de Estudos e Projetos-
Descrição: dc.descriptionLaboratory of Nanobiotechnology Federal University of Acre-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Medical Engineering University of Lubeck-
Descrição: dc.descriptionFederal University of Rio Grande do Norte Department of Theoretical and Experimental Physics-
Descrição: dc.descriptionDiagnostic Laboratory and Control of Infectious Diseases in The Amazon – DCDIA Institute Leonidas e Maria Deane Foundation Oswaldo Cruz, street Teresina 476 Adrianópolis-
Descrição: dc.descriptionMaterials Physics Group Physics Institute Federal University of Goiás-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationMaterials Science and Engineering C-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmino acids-
Palavras-chave: dc.subjectFlow cytometry-
Palavras-chave: dc.subjectMagnetic hyperthermia-
Palavras-chave: dc.subjectNanoparticles-
Palavras-chave: dc.subjectNanotoxicology-
Título: dc.titleEvaluation of antiplasmodial activity and cytotoxicity assays of amino acids functionalized magnetite nanoparticles: Hyperthermia and flow cytometry applications-
Aparece nas coleções:Repositório Institucional - Unesp

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