Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Federal de Goiás (UFG) | - |
Autor(es): dc.contributor | University of Sevilla | - |
Autor(es): dc.contributor | Dental School of Amazonas State University | - |
Autor(es): dc.creator | Cantiga-Silva, C. [UNESP] | - |
Autor(es): dc.creator | Estrela, C. | - |
Autor(es): dc.creator | Segura-Egea, J. J. | - |
Autor(es): dc.creator | Azevedo, J. P. [UNESP] | - |
Autor(es): dc.creator | de Oliveira, P. H.C. [UNESP] | - |
Autor(es): dc.creator | Cardoso, C. B.M. [UNESP] | - |
Autor(es): dc.creator | Pinheiro, T. N. | - |
Autor(es): dc.creator | Ervolino, E. [UNESP] | - |
Autor(es): dc.creator | Sivieri-Araújo, G. [UNESP] | - |
Autor(es): dc.creator | Cintra, L. T.A. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:50:45Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:50:45Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/iej.13519 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207586 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207586 | - |
Descrição: dc.description | Aim: To investigate the effects of liver fibrosis (LF) on the pro-inflammatory mediators and periapical bone resorption of apical periodontitis (AP) in rats. Methodology: Forty male Wistar rats were distributed into four groups: C – control, AP – rats with AP, LF – rats with LF, AP + LF – rats with AP and LF. LF was induced by carbon tetrachloride administration for 8 weeks and surgical bile duct ligation for 4 weeks; AP was induced in the teeth of rats by dental pulp exposure to the oral environment for 30 days. Jaws and livers were removed after euthanasia. Haematoxylin and Eosin (H&E) and Picrosirius Red (PSR) staining were used to confirm fibrosis in the livers. The jaws were analysed using H&E staining, immunohistochemical assays of interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α). Student’s t-test and Mann–Whitney’s U-test were used for statistical analysis (P < 0.05). Results: Inflammatory infiltrate was moderate in the AP group and severe in the AP + LF group (P < 0.05). Periapical bone resorption was significantly larger in the AP + LF group compared with the AP group (P < 0.05). IL-1β, IL-6 and TNF-α levels were significantly higher in AP + LF group when compared to the AP group (P < 0.05). Conclusion: More intense inflammatory infiltrate, greater amounts of pro-inflammatory cytokines and increased periapical bone resorption were observed in the presence of liver fibrosis in rats with exposed pulps. | - |
Descrição: dc.description | Endodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Stomatologic Sciences School of Dentistry UFG – Federal University of Goiás | - |
Descrição: dc.description | Endodontic Section Department of Stomatology School of Dentistry University of Sevilla | - |
Descrição: dc.description | Department of Oral Pathology and Oral Medicine Dental School of Amazonas State University | - |
Descrição: dc.description | Department of Basic Science School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Dental Assistance Center for Disabled Persons (CAOE) School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Endodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Basic Science School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Dental Assistance Center for Disabled Persons (CAOE) School of Dentistry São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Endodontic Journal | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | apical periodontitis | - |
Palavras-chave: dc.subject | cytokines | - |
Palavras-chave: dc.subject | inflammation | - |
Palavras-chave: dc.subject | liver fibrosis | - |
Palavras-chave: dc.subject | oral infection | - |
Título: dc.title | Inflammatory profile of apical periodontitis associated with liver fibrosis in rats: histological and immunohistochemical analysis | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: