Inflammatory profile of apical periodontitis associated with liver fibrosis in rats: histological and immunohistochemical analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversity of Sevilla-
Autor(es): dc.contributorDental School of Amazonas State University-
Autor(es): dc.creatorCantiga-Silva, C. [UNESP]-
Autor(es): dc.creatorEstrela, C.-
Autor(es): dc.creatorSegura-Egea, J. J.-
Autor(es): dc.creatorAzevedo, J. P. [UNESP]-
Autor(es): dc.creatorde Oliveira, P. H.C. [UNESP]-
Autor(es): dc.creatorCardoso, C. B.M. [UNESP]-
Autor(es): dc.creatorPinheiro, T. N.-
Autor(es): dc.creatorErvolino, E. [UNESP]-
Autor(es): dc.creatorSivieri-Araújo, G. [UNESP]-
Autor(es): dc.creatorCintra, L. T.A. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:45Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/iej.13519-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207586-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207586-
Descrição: dc.descriptionAim: To investigate the effects of liver fibrosis (LF) on the pro-inflammatory mediators and periapical bone resorption of apical periodontitis (AP) in rats. Methodology: Forty male Wistar rats were distributed into four groups: C – control, AP – rats with AP, LF – rats with LF, AP + LF – rats with AP and LF. LF was induced by carbon tetrachloride administration for 8 weeks and surgical bile duct ligation for 4 weeks; AP was induced in the teeth of rats by dental pulp exposure to the oral environment for 30 days. Jaws and livers were removed after euthanasia. Haematoxylin and Eosin (H&E) and Picrosirius Red (PSR) staining were used to confirm fibrosis in the livers. The jaws were analysed using H&E staining, immunohistochemical assays of interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α). Student’s t-test and Mann–Whitney’s U-test were used for statistical analysis (P < 0.05). Results: Inflammatory infiltrate was moderate in the AP group and severe in the AP + LF group (P < 0.05). Periapical bone resorption was significantly larger in the AP + LF group compared with the AP group (P < 0.05). IL-1β, IL-6 and TNF-α levels were significantly higher in AP + LF group when compared to the AP group (P < 0.05). Conclusion: More intense inflammatory infiltrate, greater amounts of pro-inflammatory cytokines and increased periapical bone resorption were observed in the presence of liver fibrosis in rats with exposed pulps.-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Stomatologic Sciences School of Dentistry UFG – Federal University of Goiás-
Descrição: dc.descriptionEndodontic Section Department of Stomatology School of Dentistry University of Sevilla-
Descrição: dc.descriptionDepartment of Oral Pathology and Oral Medicine Dental School of Amazonas State University-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDental Assistance Center for Disabled Persons (CAOE) School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDental Assistance Center for Disabled Persons (CAOE) School of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Endodontic Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectapical periodontitis-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectliver fibrosis-
Palavras-chave: dc.subjectoral infection-
Título: dc.titleInflammatory profile of apical periodontitis associated with liver fibrosis in rats: histological and immunohistochemical analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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