Case Report: A Possible Case of Congenital Erythropoietic Porphyria in a Gir Calf: A Clinical, Pathological, and Molecular Approach

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília-
Autor(es): dc.contributorInstituto Nacional de Investigación Agropecuaria-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorQueiroz, Cintia Regina Rêgo-
Autor(es): dc.creatorMachado, Mizael-
Autor(es): dc.creatorBromberger, Cristiana Raach [UNESP]-
Autor(es): dc.creatorOliveira-Filho, Jose Paes [UNESP]-
Autor(es): dc.creatorBorges, Alexandre Secorun [UNESP]-
Autor(es): dc.creatorSoto-Blanco, Benito-
Autor(es): dc.creatorBorges, José Renato Junqueira-
Autor(es): dc.creatorCâmara, Antônio Carlos Lopes-
Autor(es): dc.creatorCastro, Márcio Botelho de-
Data de aceite: dc.date.accessioned2022-02-22T00:50:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:31Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fvets.2021.632762-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207533-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207533-
Descrição: dc.descriptionCongenital erythropoietic porphyria (CEP) is a rare hereditary autosomal recessive disease which has never been reported in Zebu cattle. A 3-day-old Gir calf showed teeth discoloration, fever, dehydration, and dyspnea. The main gross findings were pink-colored teeth, red-brown periosteum and bone marrow, and a fluorescent bright pink coloration of the bone marrow and articular surfaces under ultraviolet light. Aggregates of periodic acid-Schiff (PAS)-stained porphyrin pigments were evident in the lungs, kidneys, and the liver. An intron 8 single-nucleotide polymorphism (SNP) in both the Gir calf and control animals, along with the absence of the uroporphyrin III synthetase (UROS) gene mutation, was observed. Most SNPs were located in the intron regions of the UROS gene without relevance for CEP. A continuous loss of genetic variability and an increase in inbreeding in some herds may be related to CEP in Gir cattle, one of the most prominent Zebu breeds worldwide. In summary, this study describes a presumptive case of CEP in a Gir calf based on clinical and pathological findings. A definitive diagnosis would require the measurement of porphyrin levels in blood, urine, or tissues or the identification of UROS gene defects.-
Descrição: dc.descriptionVeterinary Pathology Laboratory University of Brasília, Campus Darcy Ribeiro-
Descrição: dc.descriptionInstituto Nacional de Investigación Agropecuaria-
Descrição: dc.descriptionDepartment of Veterinary Clinical Science School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinics and Surgery Veterinary College Universidade Federal de Minas Gerais-
Descrição: dc.descriptionCollege of Agronomy and Veterinary Medicine Large Animal Veterinary Teaching Hospital University of Brasília-
Descrição: dc.descriptionDepartment of Veterinary Clinical Science School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Veterinary Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcattle-
Palavras-chave: dc.subjectpink teeth-
Palavras-chave: dc.subjectporphyrin-
Palavras-chave: dc.subjecturoporphyrin-
Palavras-chave: dc.subjectZebu-
Título: dc.titleCase Report: A Possible Case of Congenital Erythropoietic Porphyria in a Gir Calf: A Clinical, Pathological, and Molecular Approach-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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