Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of California-
Autor(es): dc.contributorCIEPQPF-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.creatorKurnik, Isabelle S. [UNESP]-
Autor(es): dc.creatorD'Angelo, Natália A.-
Autor(es): dc.creatorMazzola, Priscila G.-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorKamei, Daniel T.-
Autor(es): dc.creatorPereira, Jorge F. B.-
Autor(es): dc.creatorVicente, António A.-
Autor(es): dc.creatorLopes, André M.-
Data de aceite: dc.date.accessioned2022-02-22T00:50:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:28Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-21-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d0bm01884h-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207509-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207509-
Descrição: dc.descriptionWe generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The partitioning of the hydrophobic model compound curcumin (CCM) into the PM-rich phase and the drug delivery capabilities of the PMs were investigated. ATPMSs formed using more hydrophobic ILs (i.e., [Ch][Hex] ≈ [Ch][But] > [Ch][Pro] > [Ch][Ac] ≈ [Ch]Cl) were the most effective in partitioning (KCCM) and recovering (RECRich) CCM into the PM-rich phase (15.2 < KCCM < 22.0 and 90% < RECRich < 95%, respectively). Moreover, using 1.2 M [Ch][But] and 0.2 M [Ch][Hex] ILs yielded higher encapsulation efficiency (EE) (94.1 and 96.0%, respectively) and drug loading (DL) capacity (14.8 and 16.2%, respectively), together with an increase in the average hydrodynamic diameter of the PMs (DH) (42.5 and 45.6 nm, respectively). The CCM-PM formulations were stable at 4.0, 25.0, and 37.0 °C and the release of CCM was faster with the less hydrophobic ILs (i.e., [Ch]Cl and [Ch][Ac]). Furthermore, due to the lower critical solution temperature properties of Pluronic® L35, the PMs exhibit temperature responsiveness at 37.0 °C. In vitro cytotoxicity assays were also performed to determine the potency of CCM-PM formulations, and a 1.8-fold decrease in IC50 values was observed between the CCM-PMs/[Ch][Hex] and CCM-PMs/[Ch]Cl formulations for PC3 cells. The lower IC50 value for the [Ch][Hex] version corresponded to a greater potency compared to the [Ch]Cl version, since a lower concentration of CCM was required to achieve the same therapeutic effect. The ATPMSs investigated in this study serve as a novel platform for Pluronic® L35/PBS buffer (pH 7.4) + IL-based ATPMS development. The unique properties reported here may be useful in applications such as controlled-release drug delivery systems (DDS), encapsulation, and bioseparations.-
Descrição: dc.descriptionDepartment of Engineering of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of Campinas-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Bioengineering University of California-
Descrição: dc.descriptionUniversity of Coimbra CIEPQPF Department of Chemical Engineering-
Descrição: dc.descriptionCentre of Biological Engineering (CEB) University of Minho-
Descrição: dc.descriptionDepartment of Engineering of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format2183-2196-
Idioma: dc.languageen-
Relação: dc.relationBiomaterials Science-
???dc.source???: dc.sourceScopus-
Título: dc.titlePolymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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