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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.contributor | University of California | - |
Autor(es): dc.contributor | CIEPQPF | - |
Autor(es): dc.contributor | University of Minho | - |
Autor(es): dc.creator | Kurnik, Isabelle S. [UNESP] | - |
Autor(es): dc.creator | D'Angelo, Natália A. | - |
Autor(es): dc.creator | Mazzola, Priscila G. | - |
Autor(es): dc.creator | Chorilli, Marlus [UNESP] | - |
Autor(es): dc.creator | Kamei, Daniel T. | - |
Autor(es): dc.creator | Pereira, Jorge F. B. | - |
Autor(es): dc.creator | Vicente, António A. | - |
Autor(es): dc.creator | Lopes, André M. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:50:28Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:50:28Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-03-21 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1039/d0bm01884h | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207509 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207509 | - |
Descrição: dc.description | We generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The partitioning of the hydrophobic model compound curcumin (CCM) into the PM-rich phase and the drug delivery capabilities of the PMs were investigated. ATPMSs formed using more hydrophobic ILs (i.e., [Ch][Hex] ≈ [Ch][But] > [Ch][Pro] > [Ch][Ac] ≈ [Ch]Cl) were the most effective in partitioning (KCCM) and recovering (RECRich) CCM into the PM-rich phase (15.2 < KCCM < 22.0 and 90% < RECRich < 95%, respectively). Moreover, using 1.2 M [Ch][But] and 0.2 M [Ch][Hex] ILs yielded higher encapsulation efficiency (EE) (94.1 and 96.0%, respectively) and drug loading (DL) capacity (14.8 and 16.2%, respectively), together with an increase in the average hydrodynamic diameter of the PMs (DH) (42.5 and 45.6 nm, respectively). The CCM-PM formulations were stable at 4.0, 25.0, and 37.0 °C and the release of CCM was faster with the less hydrophobic ILs (i.e., [Ch]Cl and [Ch][Ac]). Furthermore, due to the lower critical solution temperature properties of Pluronic® L35, the PMs exhibit temperature responsiveness at 37.0 °C. In vitro cytotoxicity assays were also performed to determine the potency of CCM-PM formulations, and a 1.8-fold decrease in IC50 values was observed between the CCM-PMs/[Ch][Hex] and CCM-PMs/[Ch]Cl formulations for PC3 cells. The lower IC50 value for the [Ch][Hex] version corresponded to a greater potency compared to the [Ch]Cl version, since a lower concentration of CCM was required to achieve the same therapeutic effect. The ATPMSs investigated in this study serve as a novel platform for Pluronic® L35/PBS buffer (pH 7.4) + IL-based ATPMS development. The unique properties reported here may be useful in applications such as controlled-release drug delivery systems (DDS), encapsulation, and bioseparations. | - |
Descrição: dc.description | Department of Engineering of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Faculty of Pharmaceutical Sciences University of Campinas | - |
Descrição: dc.description | Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Bioengineering University of California | - |
Descrição: dc.description | University of Coimbra CIEPQPF Department of Chemical Engineering | - |
Descrição: dc.description | Centre of Biological Engineering (CEB) University of Minho | - |
Descrição: dc.description | Department of Engineering of Bioprocesses and Biotechnology School of Pharmaceutical Sciences São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP) | - |
Formato: dc.format | 2183-2196 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Biomaterials Science | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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