Pharmacodynamics of propofol and alfaxalone in rattlesnakes (Crotalus durissus)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorCopenhagen Zoo-
Autor(es): dc.contributorUniversity of Aarhus-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBertelsen, Mads F. [UNESP]-
Autor(es): dc.creatorBuchanan, Rasmus [UNESP]-
Autor(es): dc.creatorJensen, Heidi M. [UNESP]-
Autor(es): dc.creatorLeite, Cleo A.C. [UNESP]-
Autor(es): dc.creatorAbe, Augusto S.-
Autor(es): dc.creatorWang, Tobias [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:24Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2021.110935-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207487-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207487-
Descrição: dc.descriptionTo characterise the effect of two common induction agents, propofol and alfaxalone, on mean arterial blood pressure (MAP) and heart rate (HR), we equipped 19 adult South American rattlesnakes (Crotalus durissus) with an indwelling arterial catheter approximately 24 h prior to recording of baseline resting values. Then, seven snakes received alfaxalone (15 mg kg−1) intravascularly (IV) through the catheter, while groups two and three (both n = 6) received propofol (15 mg kg−1 IV). The first two groups were not handled, while the group 3 was manually restrained for 2 min for a mock injection of 0.2 ml saline into the ventral tail vein. Baseline HR was similar in all groups and handling caused a significant tachycardia (p = 0.031) in group three. When given IV to undisturbed animals, both propofol and alfaxalone induced a significant increase in HR (p = 0.0022 and p = 0.0045, respectively) lasting approximately 30 min, but with values only significantly exceeding baseline for the first 5 min for propofol and the first 10 min with alfaxalone. Handling caused a significant increase in MAP (p = 0.0313). Propofol did not affect MAP (p = 0.1064), while alfaxalone caused a marked hypertension (although only significant at 2 min; p = 0.031). Manual restraint significantly increases both HR and MAP, which may lead to a masking of true cardiovascular effects of anaesthetic agents.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCentre for Zoo and Wild Animal Health Copenhagen Zoo-
Descrição: dc.descriptionZoophysiology Department of Biology University of Aarhus-
Descrição: dc.descriptionDepartment of Physiological Sciences UFSCar-
Descrição: dc.descriptionDepartamento de Zoologia Centro de Aquicultura UNESP-
Descrição: dc.descriptionDepartamento de Zoologia Centro de Aquicultura UNESP-
Idioma: dc.languageen-
Relação: dc.relationComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnaesthesia-
Palavras-chave: dc.subjectBlood pressure-
Palavras-chave: dc.subjectCardiovascular-
Palavras-chave: dc.subjectDisturbance-
Palavras-chave: dc.subjectHeart rate-
Palavras-chave: dc.subjectReptile-
Título: dc.titlePharmacodynamics of propofol and alfaxalone in rattlesnakes (Crotalus durissus)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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