Antiproliferative activity of standardized phytopreparations from Ibervillea sonorae (S. Watson) Greene

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidad de Sonora – Blvd. Luis Donaldo Colosio esq. Rosales S/N-
Autor(es): dc.contributorUniversidad de Sonora – Avenida Universidad e Irigoyen-
Autor(es): dc.contributorUniversidad Panamericana – Augusto Rodin No. 498-
Autor(es): dc.creatorVidal-Gutiérrez, Max [UNESP]-
Autor(es): dc.creatorTorres-Moreno, Heriberto-
Autor(es): dc.creatorHernández-Gutiérrez, Salomón-
Autor(es): dc.creatorVelazquez, Carlos-
Autor(es): dc.creatorRobles-Zepeda, Ramón E.-
Autor(es): dc.creatorVilegas, Wagner [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:24Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.steroids.2021.108824-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207486-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207486-
Descrição: dc.descriptionIbervillea sonorae (Cucurbitaceae) is a medicinal plant utilized in Northwest Mexico against Diabetes and cancer. This natural product is taken orally, its presentation is capsules containing the plant's dried and powdered caudices. There is no regulation or standardized dosage that allows reproducibility of its pharmacological effects. Cucurbitacins are the main group of compounds found in I. sonorae and are known for their antiproliferative activity in cancer cells. Cucurbitacin IIb (CIIb), one of the compounds present in I. sonorae, has demonstrated in experimental models with HeLa cervical cancer cells an apoptotic and anti-tumoral activity. The objective of this study is to obtain and standardize two phytopreparations of I. sonorae based on their CIIb content, evaluate their antiproliferative activity in cancer cell lines, and compare the results with those obtained with CIIb; expecting to find phytopreparations with anti-cancer potential. APCI-IT-MSn is utilized for the identification of cucurbitacins, FT-ICR-MS/MS for the quantification of CIIb, and the MTT assay for the evaluation of the antiproliferative activity. The CIIb content was 0.67% for Fito-Ison-EtOH and 1.84% for Fito-Ison-EtOAc. In both phytopreparations, six cucurbitacins have been identified, and a seventh one not previously identified. Phytopreparations were more effective against HeLa, with IC50 of 30.0 and 18.6 µg/mL for Fito-Ison-EtOH and Fito-Ison-EtOAc, respectively. This effect is lower than observed on CIIb in HeLa (5.8 µg/mL). There are no significant differences (p > 0.05) in the antiproliferative activity between Fito-Ison-EtOAc and CIIb in A549, LS180, and MDA-MB-231 cells. Phytopreparations of I. sonorae have potential for the development of anti-cancer products.-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Araraquara – São Paulo, Brasil. Rodovia Araraquara – Jaú Km 1-
Descrição: dc.descriptionDepartamento de Ciencias Químico Biológicas y de la Salud Universidad de Sonora – Blvd. Luis Donaldo Colosio esq. Rosales S/N, Centro, Hermosillo Sonora-
Descrição: dc.descriptionDepartamento de Ciencias Químico Biológicas y Agropecuarias Universidad de Sonora – Avenida Universidad e Irigoyen, Caborca Sonora-
Descrição: dc.descriptionDepartamento de Medicina Universidad Panamericana – Augusto Rodin No. 498, Col. Insurgentes Mixcoac. Ciudad de México-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Coastal Campus of São Vicente, São Vicente, SP Praça Infante Dom Henrique s/n, CEP 11330-205-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Araraquara – São Paulo, Brasil. Rodovia Araraquara – Jaú Km 1-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Coastal Campus of São Vicente, São Vicente, SP Praça Infante Dom Henrique s/n, CEP 11330-205-
Idioma: dc.languageen-
Relação: dc.relationSteroids-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiproliferative-
Palavras-chave: dc.subjectCucurbitacin IIb-
Palavras-chave: dc.subjectCucurbitacins-
Palavras-chave: dc.subjectIbervillea sonorae-
Palavras-chave: dc.subjectPhytopreparation-
Palavras-chave: dc.subjectTriterpenes-
Título: dc.titleAntiproliferative activity of standardized phytopreparations from Ibervillea sonorae (S. Watson) Greene-
Tipo de arquivo: dc.typelivro digital-
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