Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Oeste Paulista (UNOESTE)-
Autor(es): dc.contributorUniversidade Do Oeste Paulista (UNOESTE)-
Autor(es): dc.contributorFaculty of Medicine of ABC (FMABC)-
Autor(es): dc.creatorVeras, Allice Santos Cruz [UNESP]-
Autor(es): dc.creatorGomes, Rayana Loch-
Autor(es): dc.creatorAlmeida Tavares, Maria Eduarda [UNESP]-
Autor(es): dc.creatorGiometti, Inês Cristina-
Autor(es): dc.creatorCardoso, Ana Paula Mattoso Miskulin [UNESP]-
Autor(es): dc.creatorda Costa Aguiar Alves, Beatriz-
Autor(es): dc.creatorLenquiste, Sabrina Alves-
Autor(es): dc.creatorVanderlei, Luiz Carlos Marques [UNESP]-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:20Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-85337-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207472-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207472-
Descrição: dc.descriptionThe high-fat diet (HFD) stimulates an increase in lipids and can be prejudicial for harmful to prostatic morphogenesis. Polyunsaturated fatty acid (PUFAs) have anti-inflammatory and antioxidant action in some types of cancer. The combination of aerobic physical exercise and PUFA can be more effective and reduce the risk of death. The study evaluates the effects of aerobic physical exercise associated with omega-3 (fish and chia oils), on the ventral prostate of Wistar rats those fed with HFD. Here, we report that HFD modified the final body weight and the weight gain, decreased the expression of the androgen receptor and increased prostatic inflammation via TNF-α produced damage prostatic like intraepithelial neoplasia. The supplementation with fish oil decreases final body weight, reduced BCL-2 and inflammation compared to chia oil; aerobic physical exercise associated with fish oil reduced lipids circulant and prostatic, increased proteins pro-apoptotic expression and reduced IL-6 (p < 0.0001) and TNF-α potentiating the CAT (p = 0.03) and SOD-1 (p = 0.001) expression. Additionally, the chia oil increased the NRF-2 (p < 0.0001) and GSS (p = 0.4) genes. PUFAs reduced the damage caused by excessive high-fat diet in the prostate so that there is greater effectiveness in omega-3 intake, it is necessary to associate with aerobic physical exercise.-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education School of Technology and Sciences São Paulo State University (UNESP), 19060-900, Street Roberto Simonsen-
Descrição: dc.descriptionDepartment of Physiotherapy São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Nutrition University of Oeste Paulista (UNOESTE)-
Descrição: dc.descriptionMulticentre Graduate Program in Physiological Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Veterinary Medicine Universidade Do Oeste Paulista (UNOESTE)-
Descrição: dc.descriptionFaculty of Medicine of ABC (FMABC), Santo André-
Descrição: dc.descriptionExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP)-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education School of Technology and Sciences São Paulo State University (UNESP), 19060-900, Street Roberto Simonsen-
Descrição: dc.descriptionDepartment of Physiotherapy São Paulo State University (UNESP)-
Descrição: dc.descriptionMulticentre Graduate Program in Physiological Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleSupplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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