SNPs in genes encoding for IL-10, TNF-α, and NFκB p105/p50 are associated with clinical prognostic factors for patients with Hodgkin lymphoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorGaiolla, Rafael Dezen [UNESP]-
Autor(es): dc.creatorde Toledo Moraes, Marcelo Padovani [UNESP]-
Autor(es): dc.creatorde Oliveira, Deilson Elgui [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:20Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0248259-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207469-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207469-
Descrição: dc.descriptionClassical Hodgkin lymphoma (cHL) is a B-cell-derived malignant neoplasia that has a unique histological distribution, in which the scarce malignant Hodgkin and Reed-Sternberg cells are surrounded by nonmalignant inflammatory cells. The interactions between the malignant and inflammatory cells are mediated by aberrantly produced cytokines, which play an important role in tumor immunopathogenesis. Single nucleotide polymorphisms (SNPs) in genes encoding cytokines and their regulatory proteins may influence the peripheral levels of these molecules and affect disease’s pathobiology. In this study, we evaluate SNPs in the promoter regions of the genes encoding for two key cytokines in Hodgkin lymphoma: IL-10 (SNP/pIL10–592, rs1800872; and SNP/pIL10–1082, rs1800896) and TNF-α (SNP/pTNF -238, rs361525; and SNP/pTNF -862, rs1800630), as well as an SNP in the intronic region of the NFκB1 gene (SNP/iNFKB1, rs1585215), an important regulator of cytokine gene expression. We then look to their possible association with clinical and laboratory features in cHL patients. Seventy-three patients with cHL are genotyped by qPCR-high resolution melting. The SNPs’ genotypes are analyzed individually for each SNP, and when more than two allelic combinations are identified, the genotypes are also divided into two groups according to proposed biological relevance. By univariate analysis, patients harboring SNP/pTNF -238 AG genotype more frequently have EBV-associated cHL compared to homozygous GG, whereas the presence of mediastinal disease (bulky and nonbulky) is more common in the pIL10–592 AC/CC group compared to the AA homozygous group. Patients with SNP/iNFKB1 AA genotype more frequently have stage IV and extranodal disease at diagnosis. These results indicate that some SNPs’ genotypes for IL-10 and TNF-α genes are associated with prognostic parameters in cHL. For the first time, the SNP/iNFKB1 is described in association with clinical features of the disease.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionViral Carcinogenesis and Cancer Biology Research Group (ViriCan) Institute of Biotechnology (IBTEC) São Paulo State University (UNESP)-
Descrição: dc.descriptionHematology Department of Internal Medicine Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionViral Carcinogenesis and Cancer Biology Research Group (ViriCan) Institute of Biotechnology (IBTEC) São Paulo State University (UNESP)-
Descrição: dc.descriptionHematology Department of Internal Medicine Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleSNPs in genes encoding for IL-10, TNF-α, and NFκB p105/p50 are associated with clinical prognostic factors for patients with Hodgkin lymphoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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