Statherin-derived peptides as antifungal strategy against Candida albicans

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Saskatchewan-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorPellissari, Claudia Viviane Guimarães [UNESP]-
Autor(es): dc.creatorJorge, Janaina Habib [UNESP]-
Autor(es): dc.creatorMarin, Lina Maria-
Autor(es): dc.creatorSabino-Silva, Robinson-
Autor(es): dc.creatorSiqueira, Walter Luiz-
Data de aceite: dc.date.accessioned2022-02-22T00:50:17Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:17Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2021.105106-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207449-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207449-
Descrição: dc.descriptionObjective: The aim of this in vitro study was to evaluate the effect of statherin and its naturally occurring peptides (DR9-2, DR9, GE-12, IT-32, GQ-19, IP-18) on Candida albicans metabolism and biofilm development. Design: After the killing assay, a peptide pellicle was formed on the bottom of a polystyrene plate at the IC50 of each peptide. Over the peptide pellicle, Candida albicans biofilm (48 h) was grown. The peptides antimicrobial activity after the peptides treatment was evaluated by alamarBlue, total biofilm biomass and colony forming units (CFU) counting. Results: The pellicle with statherin and the peptides (DR9-2, DR9, GE-12, IP-18, GQ-19) was able to reduce he viability of Candida albicans compared to the negative control. They also decreased cell proliferation by 20 % and total biomass. IT-32 showed the highest reduction in cell proliferation and biomass, which was similar to the positive control, histatin 5. Conclusions: These results suggest that the naturally occuring peptides from statherin are able to decrease Candida albicans colonization and biofilm proliferation.-
Descrição: dc.descriptionCanadian Institutes of Health Research-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araraquara Dental School São Paulo State University UNESP, 1680 Rua Humaitá-
Descrição: dc.descriptionCollege of Dentistry University of Saskatchewan, 105 Wiggins Road-
Descrição: dc.descriptionDepartment of Physiology Institute of Biomedical Sciences Federal University of Uberlandia, 3Q – 2121 Av. João Naves de Ávila-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araraquara Dental School São Paulo State University UNESP, 1680 Rua Humaitá-
Descrição: dc.descriptionCanadian Institutes of Health Research: # 106657-
Descrição: dc.descriptionFAPESP: # 2015/06016-1-
Descrição: dc.descriptionCanadian Institutes of Health Research: # 400347-
Descrição: dc.descriptionFAPESP: #2016/03847-2-
Descrição: dc.descriptionFAPESP: #2018/13904-9-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal activity-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectStomatitis-
Título: dc.titleStatherin-derived peptides as antifungal strategy against Candida albicans-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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