Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorMillennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R)-
Autor(es): dc.contributorUniversidad Andres Bello-
Autor(es): dc.contributorUniversidad del Desarrollo-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.creatorSalgado-Caxito, Marília [UNESP]-
Autor(es): dc.creatorBenavides, Julio A.-
Autor(es): dc.creatorMunita, Jose M.-
Autor(es): dc.creatorRivas, Lina-
Autor(es): dc.creatorGarcía, Patricia-
Autor(es): dc.creatorListoni, Fernando J.P. [UNESP]-
Autor(es): dc.creatorMoreno-Switt, Andrea I.-
Autor(es): dc.creatorPaes, Antonio C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:14Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.prevetmed.2021.105316-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207432-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207432-
Descrição: dc.descriptionFaecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R E. coli) in dogs has been reported worldwide and can reduce the effectiveness of treatments against bacterial infections. However, the drivers that influence faecal carriage of ESC-R E. coli in dogs are poorly understood. The aims of this study were to estimate the prevalence of ESC-R E. coli among dogs prior to their admission to a veterinary teaching hospital and to identify risk factors associated with the faecal carriage of ESC-R E. coli. Rectal swabs (n = 130) were collected from dogs and screened for ESC-R E. coli using MacConkey agar supplemented with cefotaxime (2 μg/mL). E. coli species was confirmed by MALDI-TOF and screening of extended-spectrum beta-lactamase (ESBL) genes was conducted by multiplex PCR. Questionnaires were completed by each dog's owner to test several human and dog characteristics associated with ESC-R E. coli. The prevalence of faecal carriage of ESC-R E. coli was 9.2 % and 67 % of ESC-R E. coli isolates harboured ESBL genes including CTX-M alone or in combination with TEM. All ESC-R E. coli isolates were resistant to ceftriaxone, cefpodoxime, and cefotaxime and were susceptible to cefoxitin and carbapenems. The likelihood of carrying ESC-R E. coli was 15 times higher (OR = 14.41 [95 % CI: 1.80−38.02], p < 0.01) if the dog was treated with antibiotics 3–12 months prior to sampling and 8 times higher (OR = 7.96 [95 % CI: 2.96−92.07], p < 0.01) if the dog had direct contact with livestock, but 15 times lower (OR = 0.07 [95 % CI: 0.01−0.32], p < 0.01) if the dog was dewormed during the previous year. Our findings confirm the faecal carriage of ESC-R E. coli in subclinical dogs and call for further investigation regarding the impact of deworming on antibiotic-resistant bacteria in companion animals.-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Sao Paulo State University (UNESP)-
Descrição: dc.descriptionMillennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R)-
Descrição: dc.descriptionDepartamento de Ecología y Biodiversidad Facultad de Ciencias de la Vida Universidad Andres Bello-
Descrição: dc.descriptionCentro de Investigación para la Sustentabilidad Universidad Andres Bello, Facultad de Ciencias de la Vida-
Descrição: dc.descriptionGenomics and Resistant Microbes Group Facultad de Medicina Clínica Alemana Universidad del Desarrollo-
Descrição: dc.descriptionEscuela de Medicina Facultad de Medicina Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionEscuela de Medicina Veterinaria Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine School of Veterinary Medicine and Animal Science Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPreventive Veterinary Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial resistance-
Palavras-chave: dc.subjectCompanion animals-
Palavras-chave: dc.subjectDeworming-
Palavras-chave: dc.subjectE. coli-
Palavras-chave: dc.subjectExtended-spectrum beta-lactamase-
Palavras-chave: dc.subjectLatin America-
Título: dc.titleRisk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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