Effects of arginase genetic polymorphisms on nitric oxide formation in healthy pregnancy and in preeclampsia

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorPinto-Souza, Caroline C. [UNESP]-
Autor(es): dc.creatorCoeli-Lacchini, Fernanda-
Autor(es): dc.creatorLuizon, Marcelo R.-
Autor(es): dc.creatorCavalli, Ricardo C.-
Autor(es): dc.creatorLacchini, Riccardo-
Autor(es): dc.creatorSandrim, Valeria C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:07Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.niox.2021.02.003-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207391-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207391-
Descrição: dc.descriptionBackground and aims: Preeclampsia is associated with reduced nitric oxide (NO) bioavailability. Arginase is related to NO synthesis, but relatively unexplored in preeclampsia. However, no previous study has examined whether variations in ARG1 and ARG2 genes affect NO bioavailability and the risk of preeclampsia. Here, we compared the alleles and genotypes of single nucleotide polymorphisms (SNPs) in ARG1 (rs2781659; rs2781667; rs2246012; rs17599586) and ARG2 (rs3742879; rs10483801) in healthy pregnant women and preeclampsia, and examined whether these SNPs affect plasma nitrite concentrations (a marker of NO formation) in these groups. Methods: Genotypes for the ARG1 and ARG2 SNPs were determined by Taqman probe and plasma nitrite by an ozone-based chemiluminescence assay. Results: Regarding ARG1 SNPs, the GG genotype and G allele frequencies for rs2781659, and the C allele frequencies for rs2246012 were higher in preeclampsia compared to healthy pregnant women. Moreover, the GG genotype for rs2781659 and the TT genotype for rs2781667 were associated with higher plasma nitrite in healthy pregnant. We found no association of ARG2 polymorphisms with preeclampsia or nitrite levels in the study groups. Conclusions: Our results suggest that SNPs of ARG1 increase the risk of preeclampsia and modulate plasma nitrite levels in healthy pregnant women.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior-
Descrição: dc.descriptionDepartment of Clinical Analyses Toxicology and Food Science School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo (USP)-
Descrição: dc.descriptionDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo-
Descrição: dc.descriptionDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto School of Nursing University of Sao Paulo (USP)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 2014-5/305587-
Descrição: dc.descriptionFAPESP: 2019/07230-8-
Formato: dc.format20-25-
Idioma: dc.languageen-
Relação: dc.relationNitric Oxide - Biology and Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArginase-
Palavras-chave: dc.subjectGenetic polymorphisms-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectNitrite-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectPregnancy-
Título: dc.titleEffects of arginase genetic polymorphisms on nitric oxide formation in healthy pregnancy and in preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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