Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed)

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorThe University of Edinburgh-
Autor(es): dc.contributorUniversity of Zürich-
Autor(es): dc.contributorGhent University-
Autor(es): dc.creatorOliveira, Alice Rodrigues de [UNESP]-
Autor(es): dc.creatorGozalo-Marcilla, Miguel-
Autor(es): dc.creatorRinger, Simone Katja-
Autor(es): dc.creatorSchauvliege, Stijn-
Autor(es): dc.creatorFonseca, Mariana Werneck [UNESP]-
Autor(es): dc.creatorTrindade, Pedro Henrique Esteves [UNESP]-
Autor(es): dc.creatorPuoli Filho, José Nicolau Prospero [UNESP]-
Autor(es): dc.creatorLuna, Stelio Pacca Loureiro [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:50:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:06Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-02-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fvets.2021.611729-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207389-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207389-
Descrição: dc.descriptionThe lack of standardization of sedation scales in horses limits the reproducibility between different studies. This prospective, randomized, blinded, horizontal and controlled trial aimed to validate a scale for sedation in horses (EquiSed). Seven horses were treated with intravenous detomidine in low/high doses alone (DL 2.5 μg/kg + 6.25 μg/kg/h; DH 5 μg/kg +12.5 μg/kg/h) or associated with methadone (DLM and DHM, 0.2 mg/kg + 0.05 mg/kg/h) and with low (ACPL 0.02 mg/kg) or high (ACPH 0.09 mg/kg) doses of acepromazine alone. Horses were filmed at (i) baseline (ii) peak, (iii) intermediate, and (iv) end of sedation immediately before auditory, visual and pressure stimuli were applied and postural instability evaluated for another study. Videos were randomized and blindly evaluated by four evaluators in two phases with 1-month interval. Intra- and interobserver reliability of the sum of EquiSed (Intraclass correlation coefficient) ranged between 0.84–0.94 and 0.45–0.88, respectively. The criterion validity was endorsed by the high Spearman correlation between the EquiSed and visual analog (0.77), numerical rating (0.76), and simple descriptive scales (0.70), and average correlation with head height above the ground (HHAG) (−0.52). The Friedman test confirmed the EquiSed responsiveness over time. The principal component analysis showed that all items of the scale had a load factor ≥ 0.50. The item-total Spearman correlation for all items ranged from 0.3 to 0.5, and the internal consistency was good (Cronbach's α = 0.73). The area under the curve of EquiSed HHAG as a predictive diagnostic measure was 0.88. The sensitivity of the EquiSed calculated according to the cut-off point (score 7 of the sum of the EquiSed) determined by the receiver operating characteristic curve, was 96% and specificity was 83%. EquiSed has good intra- and interobserver reliabilities and is valid to evaluate tranquilization and sedation in horses.-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionThe Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh-
Descrição: dc.descriptionSection Anaesthesiology Department of Clinical Diagnostics and Services Vetsuisse Faculty University of Zürich-
Descrição: dc.descriptionDepartment of Surgery and Anaesthesia of Domestic Animals Faculty of Veterinary Medicine Ghent University-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University Universidade Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Veterinary Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectacepromazine maleate-
Palavras-chave: dc.subjectdetomidine-
Palavras-chave: dc.subjecthorses-
Palavras-chave: dc.subjectmethadone-
Palavras-chave: dc.subjectscales-
Palavras-chave: dc.subjectα-2 adrenergic receptor agonist-
Título: dc.titleDevelopment, Validation, and Reliability of a Sedation Scale in Horses (EquiSed)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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