Prenatal and pubertal exposure to 17α-ethinylestradiol disrupts folliculogenesis and promotes morphophysiological changes in ovaries of old gerbils (Meriones unguiculatus)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUFJ-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorDe Souza, Vinícius Gonçalves-
Autor(es): dc.creatorBandeira, Laura Borges-
Autor(es): dc.creatorSouza, Nátaly Caroline Silva E-
Autor(es): dc.creatorTaboga, Sebastião Roberto [UNESP]-
Autor(es): dc.creatorMartins, Tracy Martina Marques-
Autor(es): dc.creatorSilva Perez, Ana Paula-
Data de aceite: dc.date.accessioned2022-02-22T00:50:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:06Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S2040174421000040-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207387-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207387-
Descrição: dc.description17α-Ethinylestradiol is an endocrine-disrupting chemical that make up most contraceptive pills and can be found in the environment. Exposure to ethinylestradiol in different development periods may promote changes in morphophysiological parameters of reproductive and endocrine organs. Considering that the effects of low doses (15 μg/kg/day) of ethinylestradiol in ovaries from 12-month-old female gerbils (Meriones unguiculatus) were investigated. Four experimental groups used were control (without treatment), EE/PRE (treated from the 18th to the 22nd gestational day), EE/PUB (treated from the 42nd to the 49th day of life), and EE/PRE-PUB (treated in the both periods). The animals were euthanized at 12 months. Testosterone and 17β-estradiol levels were measured. The ovaries were stained with Hematoxylin and Eosin, Periodic Acid Schiff, and Gomori's Trichome. The follicles, corpus luteum, interstitial gland, lipofuscin, ovarian epithelium, and tunica albuginea were analyzed. Estradiol was higher in EE/PRE and EE/PUB groups, while testosterone was higher only in EE/PUB group. The main changes in follicle count occurred in EE/PUB and EE/PRE-PUB groups, with higher primordial follicle count and lower maturation of follicles. The corpus luteum was more evident in EE/PRE group. No differences were found in atretic follicles count. A higher area occupied by interstitial gland cells and lipofuscin deposit in these cells was noted in EE/PUB and EE/PRE-PUB groups. Higher epithelium height and thicker tunic albuginea were showed in treated groups. These results suggest that exposure to doses of EE2 in prenatal and pubertal periods of the development leads to morphological changes in senile ovaries.-
Descrição: dc.descriptionInstitute of Health Sciences Medicine Course Federal University of Jataí UFJ-
Descrição: dc.descriptionDepartment of Biology Laboratory of Microscopy and Microanalysis São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology State University of Campinas UNICAMP-
Descrição: dc.descriptionInstitute of Health Sciences Medicine Course and Graduate Program of Animal Bioscience Federal University of Jataí UFJ-
Descrição: dc.descriptionDepartment of Biology Laboratory of Microscopy and Microanalysis São Paulo State University-UNESP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Developmental Origins of Health and Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcontraceptive agents-
Palavras-chave: dc.subjectendocrine disruptors-
Palavras-chave: dc.subjectGerbillinae-
Palavras-chave: dc.subjectKeywords:-
Palavras-chave: dc.subjectovary-
Título: dc.titlePrenatal and pubertal exposure to 17α-ethinylestradiol disrupts folliculogenesis and promotes morphophysiological changes in ovaries of old gerbils (Meriones unguiculatus)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.