Gutting it Out: Developing Effective Immunotherapies for Patients with Colorectal Cancer

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstitute of Biosciences of Botucatu-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorDAMP Laboratory-
Autor(es): dc.contributorUniversity of Pittsburgh-
Autor(es): dc.contributorSorbonne University-
Autor(es): dc.contributorJohns Hopkins School of Medicine-
Autor(es): dc.creatorMendonça Gorgulho, Carolina [UNESP]-
Autor(es): dc.creatorKrishnamurthy, Anuradha-
Autor(es): dc.creatorLanzi, Anastasia-
Autor(es): dc.creatorGalon, Jérôme-
Autor(es): dc.creatorHousseau, Franck-
Autor(es): dc.creatorKaneno, Ramon [UNESP]-
Autor(es): dc.creatorLotze, Michael T.-
Data de aceite: dc.date.accessioned2022-02-22T00:50:01Z-
Data de disponibilização: dc.date.available2022-02-22T00:50:01Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/CJI.0000000000000357-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207369-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207369-
Descrição: dc.descriptionRisk factors for colorectal cancer (CRC) include proinflammatory diets, sedentary habits, and obesity, in addition to genetic syndromes that predispose individuals to this disease. Current treatment relies on surgical excision and cytotoxic chemotherapies. There has been a renewed interest in immunotherapy as a treatment option for CRC given the success in melanoma and microsatellite instable (MSI) CRC. Immunotherapy with checkpoint inhibitors only plays a role in the 4%-6% of patients with MSIhightumors and even within this subpopulation, response rates can vary from 30% to 50%. Most patients with CRC do not respond to this modality of treatment, even though colorectal tumors are frequently infiltrated with T cells. Tumor cells limit apoptosis and survive following intensive chemotherapy leading to drug resistance and induction of autophagy. Pharmacological or molecular inhibition of autophagy improves the efficacy of cytotoxic chemotherapy in murine models. The microbiome clearly plays an etiologic role, in some or most colon tumors, realized by elegant findings in murine models and now investigated in human clinical trials. Recent results have suggested that cancer vaccines may be beneficial, perhaps best as preventive strategies. The search for therapies that can be combined with current approaches to increase their efficacy, and new knowledge of the biology of CRC are pivotal to improve the care of patients suffering from this disease. Here, we review the basic immunobiology of CRC, current state-of-the-art immunotherapies and define those areas with greatest therapeutic promise for the future.-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences of Botucatu-
Descrição: dc.descriptionDepartment of Pathology School of Medicine of Botucatu São Paulo State University UNESP-
Descrição: dc.descriptionDAMP Laboratory Department of Surgery-
Descrição: dc.descriptionDepartment of Medicine University of Pittsburgh-
Descrição: dc.descriptionINSERM Laboratory of Integrative Cancer Immunology League Against Cancer Cordeliers Research Center Sorbonne University-
Descrição: dc.descriptionSidney Kimmel Comprehensive Cancer Centre Johns Hopkins School of Medicine-
Descrição: dc.descriptionDepartment of Pathology School of Medicine of Botucatu São Paulo State University UNESP-
Formato: dc.format49-62-
Idioma: dc.languageen-
Relação: dc.relationJournal of Immunotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectautophagy-
Palavras-chave: dc.subjectchemoresistance-
Palavras-chave: dc.subjectcolorectal cancer-
Palavras-chave: dc.subjectDAMPs-
Palavras-chave: dc.subjectdendritic cells-
Palavras-chave: dc.subjectHMGB1-
Palavras-chave: dc.subjectImmunoscore-
Palavras-chave: dc.subjectimmunotherapy-
Palavras-chave: dc.subjectmicrobiome-
Palavras-chave: dc.subjectT cells-
Título: dc.titleGutting it Out: Developing Effective Immunotherapies for Patients with Colorectal Cancer-
Aparece nas coleções:Repositório Institucional - Unesp

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