Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCentro Universitário Estácio de Ribeirão Preto-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorClínica de Anestesiologia de Ribeirão Preto (CARP)-
Autor(es): dc.contributorPontifícia Universidade Católica de Campinas (PUC-CAMPINAS)-
Autor(es): dc.creatorFilho, Marcos Antonio Marton [UNESP]-
Autor(es): dc.creatorAlves, Rodrigo Leal-
Autor(es): dc.creatordo Nascimento, Paulo [UNESP]-
Autor(es): dc.creatordos Santos Tarquinio, Gabriel-
Autor(es): dc.creatorMega, Paulo Ferreira-
Autor(es): dc.creatorMódolo, Norma Sueli Pinheiro [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0247088-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207329-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207329-
Descrição: dc.descriptionBackground Increased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers. Methods This randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant. Results In total, 64 patients completed the study-33 were given standard pressure and 31 were given low pressure. There was no significant difference in the biomarker between the groups (P = 0.580), but there was a significant difference between the time points with elevation at T1 (P < 0.001). Similar to NGAL, cystatin C had an elevation at T1 in both groups (P = 0.021), but no difference was found when comparing the groups. Conclusions In laparoscopic cholecystectomy, pneumoperitoneum increases NGAL and cystatin C levels intraoperatively, and the use of low-pressure pneumoperitoneum does not change the course of these biomarkers.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Surgical Specialties and Anesthesiology Botucatu School of Medicine Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCentro Universitário Estácio de Ribeirão Preto-
Descrição: dc.descriptionDepartment of Anesthesiology São Rafael Hospital Federal University of Bahia-
Descrição: dc.descriptionClínica de Anestesiologia de Ribeirão Preto (CARP)-
Descrição: dc.descriptionSchool of Medicine Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)-
Descrição: dc.descriptionDepartment of Surgical Specialties and Anesthesiology Botucatu School of Medicine Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionFAPESP: 2017/27032-0-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleEffects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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