Potential health and economic impacts of dexamethasone treatment for patients with COVID-19

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Autor(es): dc.contributorUniversity of Oxford-
Autor(es): dc.contributorNuffield Department of Population Health-
Autor(es): dc.contributorWorld Health Organization-
Autor(es): dc.contributorPublic Fund “Institution of social development” in the Kyrgyz Republic-
Autor(es): dc.contributorUniversitas Sumatera Utara-
Autor(es): dc.contributorUniversidade da Paz-
Autor(es): dc.contributorUSAID Mission in the Kyrgyz Republic-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.contributorOxford Policy Management-
Autor(es): dc.contributorFederal University-
Autor(es): dc.contributorUniversity of Health Sciences-
Autor(es): dc.contributorUniversity of Yaounde-
Autor(es): dc.contributorLondon School of Economics-
Autor(es): dc.contributorCornell University-
Autor(es): dc.contributorMahidol University-
Autor(es): dc.contributorMinistry of Public Health-
Autor(es): dc.contributorCOVID-19 Task Force for North Sumatera province-
Autor(es): dc.contributorPasteur Institute of Iran-
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorMinistry of Public Health of the Kyrgyz Republic-
Autor(es): dc.contributorUniversidade Nacional Timor Lorosae-
Autor(es): dc.contributorCharles Darwin University-
Autor(es): dc.contributorIndependent researcher (no affiliation)-
Autor(es): dc.contributorUniversity of Nottingham-
Autor(es): dc.contributorPopulation Services International-
Autor(es): dc.contributorGovernment of People’s Republic of Bangladesh-
Autor(es): dc.contributorUniversity of Malaya Medical Centre-
Autor(es): dc.contributorPayame Noor University-
Autor(es): dc.contributorMalawi Ministry of Health-
Autor(es): dc.contributorUniversidad de Los Andes-
Autor(es): dc.contributorKerman University of Medical Sciences-
Autor(es): dc.contributorMedical Association in the Kyrgyz Republic-
Autor(es): dc.contributorKermanshah University of Medical Sciences-
Autor(es): dc.contributorUniversity of Malaya-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity College of London-
Autor(es): dc.contributorValid International Ltd-
Autor(es): dc.contributorSoros Foundation in the Kyrgyz Republic-
Autor(es): dc.contributorMinistry of Health Timor-Leste-
Autor(es): dc.contributorUniversity of Malaysia-
Autor(es): dc.contributorUniversity of Dhaka-
Autor(es): dc.contributorSan José State University-
Autor(es): dc.contributorUniversity of the Philippines Manila-
Autor(es): dc.contributorFiji Center for Disease Control (CDC)-
Autor(es): dc.creatorÁguas, Ricardo-
Autor(es): dc.creatorMahdi, Adam-
Autor(es): dc.creatorShretta, Rima-
Autor(es): dc.creatorHorby, Peter-
Autor(es): dc.creatorLandray, Martin-
Autor(es): dc.creatorWhite, Lisa-
Autor(es): dc.creatorArifi, Fatima-
Autor(es): dc.creatorZhumalieva, Chynar-
Autor(es): dc.creatorLubis, Inke N. D.-
Autor(es): dc.creatorMonteiro, Antoninho Benjamin-
Autor(es): dc.creatorMoldokmatova, Ainura-
Autor(es): dc.creatorChen, Siyu-
Autor(es): dc.creatorEstebesova, Aida-
Autor(es): dc.creatorHussain, Mofakhar-
Autor(es): dc.creatorLata, Dipti-
Autor(es): dc.creatorBakare, Emmanuel A.-
Autor(es): dc.creatorGetachew, Biniam-
Autor(es): dc.creatorSahak, Mohammad Nadir-
Autor(es): dc.creatorChanthavilay, Phetsavanh-
Autor(es): dc.creatorNji, Akindeh M.-
Autor(es): dc.creatorAung, Yu Nandar-
Autor(es): dc.creatorHupert, Nathaniel-
Autor(es): dc.creatorTun, Sai Thein Than-
Autor(es): dc.creatorPan-Ngum, Wirichada-
Autor(es): dc.creatorSarin, K. C.-
Autor(es): dc.creatorHarsono, Handoyo-
Autor(es): dc.creatorEybpoosh, Sana-
Autor(es): dc.creatorCoutinho, Renato Mendes-
Autor(es): dc.creatorOmoleke, Semeeh A.-
Autor(es): dc.creatorNwosu, Amen-Patrick-
Autor(es): dc.creatorLuangasanatip, Nantasit-
Autor(es): dc.creatorKutmanova, Ainura-
Autor(es): dc.creatorDooronbekova, Aizhan-
Autor(es): dc.creatorXimenes, Antonio-
Autor(es): dc.creatorMonteiro, Merita-
Autor(es): dc.creatorCelhay, Olivier-
Autor(es): dc.creatorAdib, Keyrellous-
Autor(es): dc.creatorSalim, Amel H.-
Autor(es): dc.creatorYunanda, Yuki-
Autor(es): dc.creatorFariba, Mahnaz Hossain-
Autor(es): dc.creatorAzzeri, Amirah-
Autor(es): dc.creatorHancock, Penny-
Autor(es): dc.creatorBekrizadeh, Hakim-
Autor(es): dc.creatorSaeedzai, Sayed Ataullah-
Autor(es): dc.creatorAlona, Ivana-
Autor(es): dc.creatorMzumara, Grace Wezi-
Autor(es): dc.creatorMartins, Joao-
Autor(es): dc.creatorHerrera-Diestra, Jose L.-
Autor(es): dc.creatorSharifi, Hamid-
Autor(es): dc.creatorAbdyldaev, Talant-
Autor(es): dc.creatorJamshidi, Babak-
Autor(es): dc.creatorHairi, Noran Naqiah-
Autor(es): dc.creatorNasir, Naima-
Autor(es): dc.creatorZaman, Rashid U.-
Autor(es): dc.creatorObiesie, Sopuruchukwu-
Autor(es): dc.creatorKraenkel, Roberto A. [UNESP]-
Autor(es): dc.creatorLetchford, Nicholas-
Autor(es): dc.creatorAlves, Lucsendar Raimunda Fernandes-
Autor(es): dc.creatorAdele, Sandra-
Autor(es): dc.creatorSuárez-Idueta, Lorena-
Autor(es): dc.creatorAdvani, Nicole-
Autor(es): dc.creatorMarzouk, Manar-
Autor(es): dc.creatorMabombo, Viviana-
Autor(es): dc.creatorMukambetov, Aibek-
Autor(es): dc.creatorAderoba, Adeniyi Kolade-
Autor(es): dc.creatorTbalasubramaniam, Bpriya Lakshmy-
Autor(es): dc.creatorde Colombi, Nicole Feune-
Autor(es): dc.creatorNiha, Maria Angela Varela-
Autor(es): dc.creatorObando, Francisco-
Autor(es): dc.creatorWattanasri, Parinda-
Autor(es): dc.creatorSaralamba, Sompob-
Autor(es): dc.creatorShabaruddin, Fatiha-
Autor(es): dc.creatorShimul, Shafiun Nahin-
Autor(es): dc.creatorDahlui, Maznah-
Autor(es): dc.creatorNaidoo, Reshania-
Autor(es): dc.creatorFranco, Caroline [UNESP]-
Autor(es): dc.creatorKlein, Michael G.-
Autor(es): dc.creatorKubatova, Aisuluu-
Autor(es): dc.creatorJabin, Nusrat-
Autor(es): dc.creatorKyaw, Shwe Sin-
Autor(es): dc.creatorFreitas, Luzia Tomas-
Autor(es): dc.creatorPokharel, Sunil-
Autor(es): dc.creatorAriana, Proochista-
Autor(es): dc.creatorMercado, Chris Erwin G.-
Autor(es): dc.creatorIbragimov, Shamil-
Autor(es): dc.creatorMedina, John Robert C.-
Autor(es): dc.creatorNamedre, Mesulame-
Data de aceite: dc.date.accessioned2022-02-22T00:49:50Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:50Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41467-021-21134-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207306-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207306-
Descrição: dc.descriptionDexamethasone can reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment were to be rolled out in the UK and globally, as well as the cost-effectiveness of implementing this intervention. Assuming SARS-CoV-2 exposure levels of 5% to 15%, we estimate that, for the UK, approximately 12,000 (4,250 - 27,000) lives could be saved between July and December 2020. Assuming that dexamethasone has a similar effect size in settings where access to oxygen therapies is limited, this would translate into approximately 650,000 (240,000 - 1,400,000) lives saved globally over the same time period. If dexamethasone acts differently in these settings, the impact could be less than half of this value. To estimate the full potential of dexamethasone in the global fight against COVID-19, it is essential to perform clinical research in settings with limited access to oxygen and/or ventilators, for example in low- and middle-income countries.-
Descrição: dc.descriptionLi Ka Shing Foundation-
Descrição: dc.descriptionMedical Research Council-
Descrição: dc.descriptionNational Institute for Health Research-
Descrição: dc.descriptionNuffield College, University of Oxford-
Descrição: dc.descriptionMahidol-Oxford Tropical Medicine Research Unit Nuffield Department of Medicine University of Oxford-
Descrição: dc.descriptionInstitute of Biomedical Engineering Department of Engineering Science University of Oxford-
Descrição: dc.descriptionBig Data Institute Li Ka Shing Centre for Health Information and Discovery Nuffield Department of Medicine University of Oxford-
Descrição: dc.descriptionCentre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford-
Descrição: dc.descriptionMedical Research Council Population Health Research Unit at the University of Oxford Nuffield Department of Population Health-
Descrição: dc.descriptionWorld Health Organization-
Descrição: dc.descriptionPublic Fund “Institution of social development” in the Kyrgyz Republic-
Descrição: dc.descriptionDepartment of Paediatrics Faculty of Medicine Universitas Sumatera Utara-
Descrição: dc.descriptionUniversidade da Paz-
Descrição: dc.descriptionUSAID Mission in the Kyrgyz Republic-
Descrição: dc.descriptionInstitute of Health Policy Management and Evaluation University of Toronto-
Descrição: dc.descriptionOxford Policy Management-
Descrição: dc.descriptionDepartment of Mathematics Federal University-
Descrição: dc.descriptionStop Transmission of Polio Program (STOP) program World Health Organization-
Descrição: dc.descriptionInstitute of Research and Education Development University of Health Sciences-
Descrição: dc.descriptionLaboratory for Public Health Research biotechnology Biotechnology Center University of Yaounde-
Descrição: dc.descriptionLondon School of Economics-
Descrição: dc.descriptionDepartment of Medicine Weill Cornell Medicine and Cornell Institute for Disease and Disaster Preparedness Cornell University-
Descrição: dc.descriptionMathematical And Economic MODelling Group Mahidol-Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University-
Descrição: dc.descriptionHealth Intervention and Technology Assessment Program (HITAP) Ministry of Public Health-
Descrição: dc.descriptionCOVID-19 Task Force for North Sumatera province-
Descrição: dc.descriptionDepartment of Epidemiology and Biostatistics Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran-
Descrição: dc.descriptionCenter for Mathematics Computation and Cognition Federal University of ABC-
Descrição: dc.descriptionNuffield Department of Medicine University of Oxford-
Descrição: dc.descriptionMinistry of Public Health of the Kyrgyz Republic-
Descrição: dc.descriptionUniversidade Nacional Timor Lorosae-
Descrição: dc.descriptionMenzies School of Health Research Charles Darwin University-
Descrição: dc.descriptionIndependent researcher (no affiliation)-
Descrição: dc.descriptionUniversity of Nottingham-
Descrição: dc.descriptionPopulation Services International-
Descrição: dc.descriptionDepartment of Community Medicine Faculty of Medicine Universitas Sumatera Utara-
Descrição: dc.descriptionGovernment of People’s Republic of Bangladesh-
Descrição: dc.descriptionDepartment of Research Development and Innovation University of Malaya Medical Centre-
Descrição: dc.descriptionDepartment of Statistics Payame Noor University-
Descrição: dc.descriptionMinistry of Public Health-
Descrição: dc.descriptionMalawi Ministry of Health-
Descrição: dc.descriptionCentro de Simulacion y Modelos (CeSiMo) Universidad de Los Andes-
Descrição: dc.descriptionHIV/STI Surveillance Research Center and WHO Collaborating Center for HIV Surveillance Institute for Futures Studies in Health Kerman University of Medical Sciences-
Descrição: dc.descriptionMedical Association in the Kyrgyz Republic-
Descrição: dc.descriptionDepartment of Biostatistics Kermanshah University of Medical Sciences-
Descrição: dc.descriptionUniversity of Malaya-
Descrição: dc.descriptionInstitute for Theoretical Physics São Paulo State University (UNESP)-
Descrição: dc.descriptionUniversity College of London-
Descrição: dc.descriptionValid International Ltd-
Descrição: dc.descriptionSoros Foundation in the Kyrgyz Republic-
Descrição: dc.descriptionMinistry of Health Timor-Leste-
Descrição: dc.descriptionPEAK Urban and Oxford Martin Informal Cities Programmes COMPAS School of Anthropology and Museum Ethnography University of Oxford-
Descrição: dc.descriptionFaculty of Pharmacy University of Malaysia-
Descrição: dc.descriptionInstitute of Health Economics University of Dhaka-
Descrição: dc.descriptionDepartment of Social and Preventive Medicine Faculty of Medicine University of Malaya-
Descrição: dc.descriptionDepartment of Marketing & Business Analytics Lucas College and Graduate School of Business San José State University-
Descrição: dc.descriptionDepartment of Epidemiology and Biostatistics College of Public Health University of the Philippines Manila-
Descrição: dc.descriptionFiji Center for Disease Control (CDC)-
Descrição: dc.descriptionInstitute for Theoretical Physics São Paulo State University (UNESP)-
Descrição: dc.descriptionNuffield College, University of Oxford: COVID-19 Research Response Fund-
Idioma: dc.languageen-
Relação: dc.relationNature Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titlePotential health and economic impacts of dexamethasone treatment for patients with COVID-19-
Tipo de arquivo: dc.typelivro digital-
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