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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University Center of Hermínio Ometto Foundation–FHO | - |
Autor(es): dc.contributor | A.C.Camargo Cancer Center | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Bizinelli, Daniela | - |
Autor(es): dc.creator | Flores Navarro, Fernanda | - |
Autor(es): dc.creator | Lima Costa Faldoni, Flavia [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:49:49Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:49:49Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/01635581.2021.1882511 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/207304 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/207304 | - |
Descrição: dc.description | Maca root (Lepidium meyenii) extract is a worldwide consumed food supplement for sexual dysfunctions, increasing sperm production and its motility, and alleviating menopausal symptoms. Once maca root has a role in cell proliferation and motility, and its consumption may increase along with age, mainly in menopausal women, we aimed to investigate the plant effects on triple-negative breast cancer (TNBC) cell lines. Standardized maca root powdered extract showed significant cytotoxic activity in both MDA-MB-231 and Hs578T cells, and the IC50s were 2000 μg/ml and 3000 μg/ml, respectively. Both cell lines showed an increase in migratory capacity. Using bioinformatics tools, we established genes involved in the metastatic process, CAV1, LAMA4, and MMP-1, and the mRNAs expression was assessed by qPCR. Comparing the treated cells to the negative control, CAV1 presented a decreased expression by 2-fold in MDA-MB-231. LAMA4 presented a decrease by 4-fold in Hs578T cells. MMP-1 showed substantially increase mRNA expression in MDA-MB-231 by 86-fold and in Hs578T by 5-fold. To the best of our knowledge, this is the first study indicating that the human consumption of maca may be dangerous due to the upregulation in MMP-1 expression and the increase in TNBC migrated cells. | - |
Descrição: dc.description | University Center of Hermínio Ometto Foundation–FHO | - |
Descrição: dc.description | International Research Center A.C.Camargo Cancer Center | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Medical School São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Gynecology and Obstetrics Medical School São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Nutrition and Cancer | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Maca Root (Lepidium meyenii) Extract Increases the Expression of MMP-1 and Stimulates Migration of Triple-Negative Breast Cancer Cells | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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