Maca Root (Lepidium meyenii) Extract Increases the Expression of MMP-1 and Stimulates Migration of Triple-Negative Breast Cancer Cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity Center of Hermínio Ometto Foundation–FHO-
Autor(es): dc.contributorA.C.Camargo Cancer Center-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBizinelli, Daniela-
Autor(es): dc.creatorFlores Navarro, Fernanda-
Autor(es): dc.creatorLima Costa Faldoni, Flavia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:49Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:49Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01635581.2021.1882511-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207304-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207304-
Descrição: dc.descriptionMaca root (Lepidium meyenii) extract is a worldwide consumed food supplement for sexual dysfunctions, increasing sperm production and its motility, and alleviating menopausal symptoms. Once maca root has a role in cell proliferation and motility, and its consumption may increase along with age, mainly in menopausal women, we aimed to investigate the plant effects on triple-negative breast cancer (TNBC) cell lines. Standardized maca root powdered extract showed significant cytotoxic activity in both MDA-MB-231 and Hs578T cells, and the IC50s were 2000 μg/ml and 3000 μg/ml, respectively. Both cell lines showed an increase in migratory capacity. Using bioinformatics tools, we established genes involved in the metastatic process, CAV1, LAMA4, and MMP-1, and the mRNAs expression was assessed by qPCR. Comparing the treated cells to the negative control, CAV1 presented a decreased expression by 2-fold in MDA-MB-231. LAMA4 presented a decrease by 4-fold in Hs578T cells. MMP-1 showed substantially increase mRNA expression in MDA-MB-231 by 86-fold and in Hs578T by 5-fold. To the best of our knowledge, this is the first study indicating that the human consumption of maca may be dangerous due to the upregulation in MMP-1 expression and the increase in TNBC migrated cells.-
Descrição: dc.descriptionUniversity Center of Hermínio Ometto Foundation–FHO-
Descrição: dc.descriptionInternational Research Center A.C.Camargo Cancer Center-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Medical School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationNutrition and Cancer-
???dc.source???: dc.sourceScopus-
Título: dc.titleMaca Root (Lepidium meyenii) Extract Increases the Expression of MMP-1 and Stimulates Migration of Triple-Negative Breast Cancer Cells-
Tipo de arquivo: dc.typelivro digital-
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