Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorKarolinska Institutet-
Autor(es): dc.creatorGomes, Virgínia Juliani [UNESP]-
Autor(es): dc.creatorRezeck Nunes, Priscila [UNESP]-
Autor(es): dc.creatorHaworth, Sarah McCann-
Autor(es): dc.creatorSandrim, Valéria Cristina [UNESP]-
Autor(es): dc.creatorPeraçoli, José Carlos [UNESP]-
Autor(es): dc.creatorPeraçoli, Maria Terezinha S. [UNESP]-
Autor(es): dc.creatorCarlström, Mattias-
Data de aceite: dc.date.accessioned2022-02-22T00:49:46Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:46Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/10641955.2021.1884258-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207285-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207285-
Descrição: dc.descriptionObjective: To investigate whether the supernatant from monocytes of preeclamptic and normotensive pregnant women, cultured in vitro with silibinin, can modulate oxidative stress in HUVEC. Methods: Concentrations of IL-1β, IL-10, and TNF-α in monocyte culture supernatants were determined by ELISA. HUVEC and their supernatant cultures were employed for determination of NO, nitrite and nitrate, lipid peroxidation, and hemeoxygenase-1 (HO-1). Results: HUVEC treatment with supernatant of preeclamptic monocytes cultured with silibinin produced increased levels of nitrite, reduced lipid peroxidation, and increased HO-1. Conclusion: Supernatant of monocytes from preeclamptic women induce oxidative stress in HUVEC which can be reduced by silibinin treatment. Abbreviations: DAF-FMTM, Diaminofluorescein-FM; EDTA, Ethylenediaminetetraacetic acid; HO-1, heme oxygenase-1; HPLC, high-performance liquid chromatography; HUVEC, human umbilical vein endothelial cell; MDA, malondialdehyde; NO, nitric oxide; NT, normotensive; PE, preeclampsia; ROS, reactive oxygen species; Sb, silibinin.-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Karolinska Institutet-
Descrição: dc.descriptionDepartment of Biological and Chemical Sciences Institute of Biosciences of Botucatu Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Biological and Chemical Sciences Institute of Biosciences of Botucatu Sao Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationHypertension in Pregnancy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHUVEC-
Palavras-chave: dc.subjectmonocytes-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectpreeclampsia-
Palavras-chave: dc.subjectsilibinin-
Título: dc.titleMonocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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