Synthesis of core@shell nanoparticles functionalized with folic acid-modified PCL-co-PEGMA copolymer for methotrexate delivery

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorBrandt, João Victor [UNESP]-
Autor(es): dc.creatorPiazza, Rodolfo Debone [UNESP]-
Autor(es): dc.creatordos Santos, Caio Carvalho [UNESP]-
Autor(es): dc.creatorVega-Chacón, Jaime [UNESP]-
Autor(es): dc.creatorAmantéa, Bruno Estevam [UNESP]-
Autor(es): dc.creatorPinto, Gabriel Cardoso [UNESP]-
Autor(es): dc.creatorJafelicci, Miguel [UNESP]-
Autor(es): dc.creatorMarques, Rodrigo Fernando Costa [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:49:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:49:45Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.nanoso.2021.100675-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/207277-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/207277-
Descrição: dc.descriptionCancer is responsible for many fatalities and it is considered a public health problem. The side effects caused by conventional treatment are aggressive and painful to patients and can be reduced using nanomaterials that allows action in specific sites, making the cancer treatment more efficient, improving patient life's quality. Many kinds of nanoparticles that can be used, among these the block copolymer functionalized iron oxide nanoparticles stand out due to their simultaneous interaction with hydrophobic and hydrophilic drugs. The evaluation of these platforms properties allows optimizing their action in the human body, enhancing its biodistribution and targeting a specific region in the organism. The encapsulation efficiency and the controlled release profile is strictly dependent on the size, morphology, and interactions of the copolymer blocks. In this work, it was studied the synthesis of a hybrid nanoplatform composed of an inorganic core (iron oxide) and a polymeric shell (PCL-co-PEGMA block copolymer modified with folic acid). FTIR and 1H NMR allowed the confirmation of the nanoplatform synthesis. Particles around 180 nm stable at physiological pH were obtained, allowing its application in different regions of the human body. The encapsulation efficiency of methotrexate was approximately 95%. The drug delivery assays indicated that the nanoplatform is less active at pH 2; the presence of reduced glutathione enhanced the methotrexate release, reaching almost 50% methotrexate release after 96 h of analysis. The release efficiency of the nanoplatform allowed to identify its potential as a controlled drug delivery system.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFinanciadora de Estudos e Projetos-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP), Araraquara - SP-
Descrição: dc.descriptionLaboratory of Magnetic Materials and Colloids Department of Physical Chemistry Institute of Chemistry São Paulo State University (UNESP), Araraquara - SP-
Idioma: dc.languageen-
Relação: dc.relationNano-Structures and Nano-Objects-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectControlled release-
Palavras-chave: dc.subjectCore@shell nanoparticle-
Palavras-chave: dc.subjectMethotrexate-
Palavras-chave: dc.subjectTargeted drug delivery-
Título: dc.titleSynthesis of core@shell nanoparticles functionalized with folic acid-modified PCL-co-PEGMA copolymer for methotrexate delivery-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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